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Septerna, Inc. (SEPN) XNAS PHARMACEUTICAL PREPARATIONS Net insider selling (90d)
Latest SEPN Insider Trades
About Septerna, Inc. (SEPN) Septerna Inc is a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) oral small molecule drug discovery powered by a proprietary Native Complex Platform. Its industrial-scale platform aims to unlock the full potential of GPCR therapies. The group discovery and development of a pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic disease. Its pipeline includes SEP-786 (PTH1R), SEP-631 (MRGPRX2), TSHR, GLP-1R, GIPR, and GCGR.
Headquarters SOUTH SAN FRANCISCO, CA
Employees 130
Listed 2024
Exchange XNAS https://www.septerna.com SEC filings for SEPN on EDGAR
90-Day SEC Filing Activity Form 4 transaction type Transactions Shares Total value Open-market sale 17 1,705,230 $73.32M Grant or award 8 116,260 Option exercise 26 130,060
SEPN Insider Transactions (Form 4) 79 42 Form 4 filings on record, the earliest from Oct 28, 2024, newest first. Filing history page 1 of 2.
Recent SEPN Form 8-K Filings 5
Recent SEPN Form 144 Notices of Proposed Sale 3 A Form 144 is notice of an INTENDED sale, not a completed one. It often precedes the Form 4 that reports the trade actually happening.
Filed Filer Relationship Shares Market value Notice Aug 12, 2026 RA Capital Healthcare Fund LP affiliate 746,500 $35.97M View on EDGAR Aug 12, 2026 RA Capital Nexus Fund III, L.P. Affiliate
SEPN Insider Trading - FAQ
What is the latest insider trade for SEPN? Septerna, Inc. (SEPN) had 18 insider filings in the last 90 days, with the most recent on 2026-08-14. The full record for SEPN runs to 42 Form 4 filings, the earliest from 2024-10-28. InsiderAlpha tracks every Form 4, Form 144, and 8-K filing in real time.
How many insiders are buying SEPN stock? No insider purchases of SEPN were filed in the last 90 days. 4 purchases are on record for this company.
How many insiders are selling SEPN stock? 17 insider sales of SEPN were filed in the last 90 days, totaling $73.32M.
Where can I see SEPN SEC filings (Form 4, 10-K, 10-Q, 8-K)? This page tracks SEPN Form 4 insider transactions, Form 144 sale notices, and 8-K material event disclosures in one timeline. Annual 10-K and quarterly 10-Q reports live on the company's SEC EDGAR page.
How can I follow SEPN insider buys? Create a free InsiderAlpha account and press Watch on this page to add SEPN to your watchlist. A free account also opens the full scored daily plan with every past day and 3 months of price history. No card is required. Sign up at https://insideralpha.ai/register.
More Health Care Companies with Insider Activity Every Form 4 below links to the original document on SEC EDGAR, so the numbers on this page can be checked against the filing they came from.
Aug 14, 2026 - Third Rock Ventures V, L.P. view on EDGAR Aug 14, 2026 - RA CAPITAL MANAGEMENT, L.P. view on EDGAR Aug 13, 2026 - Elizabeth Bhatt view on EDGAR Aug 5, 2026 - Daniel D. Long view on EDGAR Jul 17, 2026 - Elizabeth Bhatt view on EDGAR Jul 2, 2026 - Daniel D. Long view on EDGAR Jun 30, 2026 - RA CAPITAL MANAGEMENT, L.P. view on EDGAR Jun 30, 2026 - Samira Shaikhly view on EDGAR Jun 30, 2026 - Abraham Bassan view on EDGAR
Related Companies - Recent Insider Activity What is SEC Form 4? The filing insiders must submit within two business days of a trade, and how to read its transaction codes. Track SEPN insider activity as it files Real-time Form 4 alerts, AI-scored daily trade ideas and 10b5-1 plan flags.
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Market cap $1.82B
P/E ratio -
Dividend yield -
Average volume 439.9K
52 week high $51.10
52 week low $11.70
Today's high $40.95
Today's low $38.74
Open $40.25
Volume 385.9K
Previous close $40.47
Shares outstanding 46.68M Market cap
$1.82B
130 employees
SEPN Insider Sentiment - Last 90 Days Share of open-market insider dollar volume that was buying versus selling, from SEC Form 4 filings.
0% Buying 100% Selling
0 insider purchases totaling $0 against 17 sales totaling $73.32M.
Most-Active SEPN Insiders - Last 90 Days 10 Dollar totals are shown for open-market purchases and sales only. Grants, option exercises, gifts and tax withholding are reported by share count because they are not trades at a market price.
Aug 11, 2026 EB Elizabeth Bhatt - Officer Option exercise Common Stock 18,681 $6.81 $127K
Aug 11, 2026 EB Elizabeth Bhatt - Officer Option exercise Common Stock 6,319 $2.76 $17K
Aug 11, 2026 EB Elizabeth Bhatt - Officer Open-market sale Common Stock 25,000 $44.00 $1.10M
Aug 11, 2026 EB Elizabeth Bhatt - Officer Option exercise Stock Option (Right to Buy) 18,681 $0.00 -
Aug 11, 2026 EB Elizabeth Bhatt - Officer Option exercise Stock Option (Right to Buy) 6,319 $0.00 -
Aug 3, 2026 DL Daniel D. Long - Officer Option exercise Common Stock 1,816 $2.76 $5K
Aug 3, 2026 DL Daniel D. Long - Officer Option exercise Common Stock 1,518 $2.76 $4K
Aug 3, 2026 DL Daniel D. Long - Officer Open-market sale Common Stock 1,000 $33.98 $34K
Aug 3, 2026 DL Daniel D. Long - Officer Open-market sale Common Stock 2,334 $34.68 $81K
Aug 3, 2026 DL Daniel D. Long - Officer Option exercise Stock Option (Right to Buy) 1,816 $0.00 -
Aug 3, 2026 DL Daniel D. Long - Officer Option exercise Stock Option (Right to Buy) 1,518 $0.00 -
Jul 15, 2026 EB Elizabeth Bhatt - Officer Option exercise Common Stock 4,000 $6.81 $27K
Jul 15, 2026 EB Elizabeth Bhatt - Officer Open-market sale Common Stock 4,000 $33.99 $136K
Jul 15, 2026 EB Elizabeth Bhatt - Officer Option exercise Stock Option (Right to Buy) 4,000 $0.00 -
Jul 1, 2026 DL Daniel D. Long - Officer Option exercise Common Stock 3,333 $2.76 $9K
Jul 1, 2026 DL Daniel D. Long - Officer Open-market sale Common Stock 2,100 $34.10 $72K
Jul 1, 2026 DL Daniel D. Long - Officer Open-market sale Common Stock 1,233 $34.81 $43K
Jul 1, 2026 DL Daniel D. Long - Officer Option exercise Stock Option (Right to Buy) 3,333 $0.00 -
Jun 29, 2026 SS Samira Shaikhly - Officer Open-market sale Common Stock 2,178 $35.18 $77K
Jun 29, 2026 SS Samira Shaikhly - Officer Option exercise Stock Option (Right to Buy) 2,178 $0.00 -
Jun 29, 2026 SS Samira Shaikhly - Officer Option exercise Common Stock 2,178 $6.81 $15K
Jun 26, 2026 AB Abraham Bassan Grant or award Stock Option (Right to Buy) 15,000 $0.00 -
Jun 26, 2026 SS Shalini Sharp Grant or award Stock Option (Right to Buy) 15,000 $0.00 -
Jun 26, 2026 BC Bernard Coulie Grant or award Stock Option (Right to Buy) 15,000 $0.00 -
Jun 26, 2026 JT Jeffrey K. Tong Grant or award Stock Option (Right to Buy) 15,000 $0.00 -
Jun 26, 2026 AE Alan Ezekowitz Grant or award Stock Option (Right to Buy) 15,000 $0.00 -
Jun 26, 2026 JS Jake Simson Grant or award Stock Option (Right to Buy) 15,000 $0.00 -
Jun 22, 2026 DL Daniel D. Long - Officer Option exercise Common Stock 10,529 $2.76 $29K
Jun 22, 2026 DL Daniel D. Long - Officer Open-market sale Common Stock 8,000 $35.10 $281K
Jun 22, 2026 DL Daniel D. Long - Officer Open-market sale Common Stock 7,000 $35.97 $252K
Jun 22, 2026 DL Daniel D. Long - Officer Option exercise Stock Option (Right to Buy) 10,529 $0.00 -
Jun 22, 2026 DL Daniel D. Long - Officer Option exercise Stock Option (Right to Buy) 4,471 $0.00 -
Jun 22, 2026 DL Daniel D. Long - Officer Option exercise Common Stock 4,471 $11.70 $52K
Jun 12, 2026 SS Samira Shaikhly - Officer Option exercise Common Stock 6,250 $11.70 $73K
Jun 12, 2026 SS Samira Shaikhly - Officer Open-market sale Common Stock 6,250 $35.08 $219K
Jun 12, 2026 SS Samira Shaikhly - Officer Option exercise Stock Option (Right to Buy) 6,250 $0.00 -
Jun 1, 2026 SS Samira Shaikhly - Officer Option exercise Common Stock 4,355 $1.55 $7K
Jun 1, 2026 SS Samira Shaikhly - Officer Option exercise Common Stock 943 $2.76 $3K
Jun 1, 2026 SS Samira Shaikhly - Officer Option exercise Common Stock 637 $2.76 $2K
Jun 1, 2026 SS Samira Shaikhly - Officer Open-market sale Common Stock 1,700 $27.78 $47K
Jun 1, 2026 SS Samira Shaikhly - Officer Open-market sale Common Stock 1,346 $28.79 $39K
Jun 1, 2026 SS Samira Shaikhly - Officer Open-market sale Common Stock 2,889 $29.66 $86K
Jun 1, 2026 SS Samira Shaikhly - Officer Option exercise Stock Option (Right to Buy) 4,355 $0.00 -
Jun 1, 2026 SS Samira Shaikhly - Officer Option exercise Stock Option (Right to Buy) 943 $0.00 -
Jun 1, 2026 SS Samira Shaikhly - Officer Option exercise Stock Option (Right to Buy) 637 $0.00 -
May 26, 2026 SS Samira Shaikhly - Officer Option exercise Common Stock 11,798 $6.81 $80K
May 26, 2026 SS Samira Shaikhly - Officer Open-market sale Common Stock 11,798 $30.06 $355K
May 26, 2026 SS Samira Shaikhly - Officer Option exercise Stock Option (Right to Buy) 11,798 $0.00 -
Apr 15, 2026 EB Elizabeth Bhatt - Officer Option exercise Common Stock 4,000 $6.81 $27K
Apr 15, 2026 EB Elizabeth Bhatt - Officer Open-market sale Common Stock 2,573 $23.76 $61K
Apr 15, 2026 EB Elizabeth Bhatt - Officer Open-market sale Common Stock 1,101 $25.24 $28K
Apr 15, 2026 EB Elizabeth Bhatt - Officer Open-market sale Common Stock 326 $25.86 $8K
Apr 15, 2026 EB Elizabeth Bhatt - Officer Option exercise Stock Option (Right to Buy) 4,000 $0.00 -
Mar 2, 2026 SS Samira Shaikhly - Officer Option exercise Stock Option (Right to Buy) 53,714 $0.00 -
Mar 2, 2026 SS Samira Shaikhly - Officer Option exercise Stock Option (Right to Buy) 11,638 $0.00 -
Mar 2, 2026 SS Samira Shaikhly - Officer Option exercise Stock Option (Right to Buy) 5,101 $0.00 -
Mar 2, 2026 SS Samira Shaikhly - Officer Option exercise Common Stock 11,638 $2.76 $32K
Mar 2, 2026 SS Samira Shaikhly - Officer Option exercise Common Stock 5,101 $2.76 $14K
Mar 2, 2026 SS Samira Shaikhly - Officer Option exercise Common Stock 53,714 $1.55 $83K
Mar 2, 2026 SS Samira Shaikhly - Officer Open-market sale Common Stock 4,090 $27.51 $112K
Mar 2, 2026 SS Samira Shaikhly - Officer Open-market sale Common Stock 66,363 $28.14 $1.87M
Feb 18, 2026 EB Elizabeth Bhatt - Officer Option exercise Common Stock 4,000 $6.81 $27K
Feb 18, 2026 EB Elizabeth Bhatt - Officer Open-market sale Common Stock 2,200 $28.46 $63K
Feb 18, 2026 EB Elizabeth Bhatt - Officer Open-market sale Common Stock 1,800 $29.58 $53K
Feb 18, 2026 EB Elizabeth Bhatt - Officer Option exercise Stock Option (Right to Buy) 4,000 $0.00 -
Feb 6, 2026 DL Daniel D. Long - Officer Grant or award Stock Option (Right to Buy) 80,000 $0.00 -
Feb 6, 2026 UK Uwe Klein - Officer Grant or award Stock Option (Right to Buy) 80,000 $0.00 -
Feb 6, 2026 SS Samira Shaikhly - Officer Grant or award Stock Option (Right to Buy) 80,000 $0.00 -
Feb 6, 2026 GL Gil M. Labrucherie - Officer Grant or award Stock Option (Right to Buy) 125,000 $0.00 -
Feb 6, 2026 JK Jae B. Kim - Officer Grant or award Stock Option (Right to Buy) 125,000 $0.00 -
Feb 6, 2026 EB Elizabeth Bhatt - Officer Grant or award Stock Option (Right to Buy) 155,000 $0.00 -
Feb 6, 2026 JF Jeffrey Finer - Officer Grant or award Stock Option (Right to Buy) 400,000 $0.00 -
Feb 6, 2026 MW Mark Andrew Wilson - Officer Grant or award Stock Option (Right to Buy) 165,000 $0.00 -
Aug 12, 2026 Third Rock Ventures V, L.P. 10% Stockholder 147,200 $7.51M View on EDGAR
$CORT
CORCEPT THERAPEUTICS INC
