OPKO HEALTH, INC. (OPK) Insider Trading & SEC Filings

Updated Jul 16, 2026 · Last SEC filing 2026-06-22

OPKO HEALTH, INC. (OPK) has filed 6 SEC Form 4 insider transactions in the last 90 days, with the most recent on 2026-06-22. 2 Form 8-K material event filings were reported by OPK in the last 90 days. InsiderAlpha tracks every OPK SEC filing — Form 4, Form 144, and 8-K — in real time, including Rule 10b5-1 plan detection.

About OPKO HEALTH, INC. (OPK)

SEC CIK	0000944809

90-Day SEC Filing Activity

Form 4 filings (90d)	6
Form 8-K filings (90d)	2
Latest Form 4 filing	2026-06-22

Recent OPK Insider Transactions (Form 4)

Date	Insider	Role	Transaction	Shares	Price	Value	Filing
2026-03-20	PAGANELLI JOHN A	Insider	P — Open-market purchase	10.0K	$1.14	$11K	SEC
2025-11-21	FROST PHILLIP MD ET AL	CEO & Chairman	P — Open-market purchase	3.9K	$1.32	$5K	SEC
2025-11-21	FROST PHILLIP MD ET AL	CEO & Chairman	P — Open-market purchase	102.4K	$1.30	$133K	SEC
2025-11-21	FROST PHILLIP MD ET AL	CEO & Chairman	P — Open-market purchase	191.5K	$1.33	$255K	SEC
2025-11-21	FROST PHILLIP MD ET AL	CEO & Chairman	P — Open-market purchase	89.4K	$1.32	$118K	SEC
2025-11-21	FROST PHILLIP MD ET AL	CEO & Chairman	P — Open-market purchase	192.9K	$1.33	$257K	SEC
2025-11-20	FROST PHILLIP MD ET AL	CEO & Chairman	P — Open-market purchase	211.9K	$1.33	$282K	SEC
2025-11-20	FROST PHILLIP MD ET AL	CEO & Chairman	P — Open-market purchase	24.6K	$1.34	$33K	SEC
2025-11-20	FROST PHILLIP MD ET AL	CEO & Chairman	P — Open-market purchase	161.8K	$1.33	$216K	SEC
2025-11-20	FROST PHILLIP MD ET AL	CEO & Chairman	P — Open-market purchase	13.7K	$1.35	$18K	SEC
2025-11-20	FROST PHILLIP MD ET AL	CEO & Chairman	P — Open-market purchase	47.1K	$1.32	$62K	SEC
2025-11-20	FROST PHILLIP MD ET AL	CEO & Chairman	P — Open-market purchase	119.1K	$1.32	$157K	SEC
2025-11-20	FROST PHILLIP MD ET AL	CEO & Chairman	P — Open-market purchase	1.8K	$1.34	$2K	SEC
2025-11-19	FROST PHILLIP MD ET AL	CEO & Chairman	P — Open-market purchase	36.3K	$1.28	$46K	SEC
2025-11-19	FROST PHILLIP MD ET AL	CEO & Chairman	P — Open-market purchase	155.5K	$1.32	$205K	SEC

All transactions sourced from SEC EDGAR Form 4 filings for OPKO HEALTH, INC. (OPK). Updated in real time as new filings are submitted to the SEC.

Most-Active OPK Insiders — Last 90 Days

Insider	Form 4 filings	Total transaction value
MEDEL ROGER MD	1	—
PFENNIGER RICHARD C JR	1	—
PAGANELLI JOHN A	1	—
UPPALURI SUBBARAO V	1	—
Yu Alice Lin-Tsing	1	—

Recent OPK Form 8-K Material Events

2026-06-18 — Item 5.07 [SEC]
2026-04-28 — Item 2.02, 9.01 [SEC]
2026-03-19 — Item 5.02 · Leadership · neutral [SEC]
OPKO Health appointed Subbarao V. Uppaluri, Ph.D. as a new independent director effective March 18, 2026. Dr. Uppaluri is a former CFO of the company (2007-2012) with extensive financial and banking experience, and will be appointed to the Compensation Committee.
2026-02-26 — Item 2.02, 9.01 · Earnings · neutral [SEC]
OPKO Health announced Q4 2025 and full-year 2025 operating and financial results on February 26, 2026, via press release. The 8-K provides no substantive financial data, guidance changes, or surprise language—it is purely a scheduling notification for a conference call to discuss

Recent Insider Filings

2026-06-22 — Lachman Prem A (Insider)
2026-06-22 — MEDEL ROGER MD (Insider)
2026-06-22 — PAGANELLI JOHN A (Insider)
2026-06-22 — PFENNIGER RICHARD C JR (Insider)
2026-06-22 — UPPALURI SUBBARAO V (Insider)

Form 4 Transaction Code Reference

SEC Form 4 transactions are reported with a one-letter code indicating the type of transaction. Common codes you'll see in OPK insider filings:

P	Open-market purchase by the insider
S	Open-market sale by the insider
A	Grant, award, or other acquisition from the issuer
M	Exercise or conversion of derivative security (e.g. options)
F	Payment of exercise price or tax liability via share withholding
G	Bona-fide gift of securities
D	Disposition to the issuer (e.g. share buyback participation)
J	Other acquisition or disposition
X	Exercise of in-the-money or at-the-money derivative security
C	Conversion of derivative security
V	Transaction voluntarily reported earlier than required

OPK Insider Trading — FAQ

What is the latest insider trade for OPK?: OPKO HEALTH, INC. (OPK) had 6 insider filings in the last 90 days, with the most recent on 2026-06-22. InsiderAlpha tracks every Form 4, 10-K, 10-Q, and 8-K filing in real time.
How many insiders are buying OPK stock?: 0 insider purchases of OPK were filed in the last 90 days.
How many insiders are selling OPK stock?: 0 insider sales of OPK were filed in the last 90 days.
Where can I see OPK SEC filings (Form 4, 10-K, 10-Q, 8-K)?: InsiderAlpha aggregates every OPK SEC filing — Form 4 insider transactions, 10-K and 10-Q quarterly reports, and 8-K material event disclosures — in one timeline.

Learn More

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