Summary
Updated Aug 31, 2026
Isaac Manke is Director of OnKure Therapeutics, Inc. (OKUR). 9 SEC Form 4 filings on record going back to 2024, most recently on 13 August 2026.
Recent Transactions
3Every recent SEC Form 4 transaction Isaac Manke has reported, most recent first.
Trading Pattern
InsiderAlpha's records for Isaac Manke go back to 2024: 9 primary Form 4 filings, an average of 3.0 per year. No transaction on record carries a Rule 10b5-1 flag - the filings look discretionary rather than pre-scheduled, which makes their timing more informative as a signal.
Other Insiders Active in the Same Stocks
Insiders who reported open-market trades in the last 12 months at the companies Isaac Manke files at. Multiple unrelated insiders buying the same stock within a short window, cluster buying, has historically been one of the strongest Form 4 signals.
- ORBIMED ADVISORS LLC - $15.00M of QTTB open-market activity in the last 12 months
- Diyong Xu - $15.00M of QTTB open-market activity in the last 12 months
- Jodie Pope Morrison - $286K of QTTB open-market activity in the last 12 months
- Lee Kalowski - $115K of QTTB open-market activity in the last 12 months
- Shelia M. Violette - $59K of QTTB open-market activity in the last 12 months
- Jason A. Leverone - $3K of OKUR open-market activity in the last 12 months
More Notable Insiders
Other corporate insiders with significant SEC Form 4 track records on InsiderAlpha:
Frequently Asked Questions
Who is Isaac Manke?
Isaac Manke is a corporate insider, tracked as Director of OnKure Therapeutics, Inc. (OKUR). InsiderAlpha holds 9 primary Form 4 filings for them, the earliest from 2024, updated as new SEC EDGAR filings are processed.
How many SEC Form 4 filings has Isaac Manke submitted recently?
5 primary Form 4 filings in the last 90 days, covering 2 companies.
Where can I see all of Isaac Manke's SEC filings?
All Form 4 filings, transaction values, and 10b5-1 plan flags are listed on this page and updated in real time as new SEC EDGAR filings are processed.
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