RHYTHM PHARMACEUTICALS, INC. (RYTM)
$107.17-$5.36 (-4.76%) Today
Yann Mazabraud - OfficerYann Mazabraud - OfficerRhythm Pharmaceuticals Inc is a commercial-stage biopharmaceutical company engaged in the development and commercialization of therapies for patients with rare neuroendocrine diseases. The company is focused on advancing its melanocortin-4 receptor (MC4R) agonists, including its main asset, IMCIVREE (setmelanotide), as a precision medicine designed to treat hyperphagia and severe obesity caused by rare MC4R pathway diseases. In addition, it has two early-stage investigational MC4R agonists in clinical development, RM-718 and bivamelagon, designed not to cause hyperpigmentation. The company is also focused on advancing potential candidates for congenital hyperinsulinism. It currently operates in two business segments: the United States, which generates maximum revenue, and International.
| Form 4 transaction type | Transactions | Shares | Total value |
|---|---|---|---|
| Open-market sale | 13 | 182,676 | $20.75M |
| Grant or award | 12 | 105,075 | |
| Option exercise | 22 | 340,510 | |
| Tax withholding / forfeiture | 1 | 2,150 |
Dollar totals are shown for open-market purchases and sales only. Grants, option exercises, gifts and tax withholding are reported by share count because they are not trades at a market price.
67 Form 4 filings on record, the earliest from Nov 8, 2024, newest first. Filing history page 2 of 3.
| Date | Insider | Transaction | Security | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Pamela J. Cramer - Officer | Grant or award | Restricted Stock Units | 11,650 | $0.00 | - | |
| Pamela J. Cramer - Officer | Grant or award | Stock Options (Right to Buy) | 17,500 | $0.00 | - | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 1,913 | $102.66 | $196K | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 700 | $103.68 | $73K | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 100 | $104.76 | $10K | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 2,266 | $98.37 | $223K | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 400 | $99.44 | $40K | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 100 | $100.85 | $10K | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 292 | $96.26 | $28K | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 400 | $97.67 | $39K | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 800 | $98.99 | $79K | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 100 | $100.10 | $10K | |
| Hunter C. Smith - Officer | Grant or award | Restricted Stock Units | 25,000 | $0.00 | - | |
| Hunter C. Smith - Officer | Grant or award | Stock Options (Right to Buy) | 37,500 | $0.00 | - | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 1,500 | $104.74 | $157K | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 1,000 | $106.60 | $107K | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 747 | $107.67 | $80K | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 3,381 | $106.06 | $359K | |
| Yann Mazabraud - Officer | Option exercise | Common Stock | 5,500 | - | - | |
| Yann Mazabraud - Officer | Option exercise | Restricted Stock Units | 5,500 | $0.00 | - | |
| Hunter C. Smith - Officer | Option exercise | Common Stock | 26,000 | - | - | |
| Hunter C. Smith - Officer | Tax withholding / forfeiture | Common Stock | 10,750 | $108.99 | $1.17M | |
| Hunter C. Smith - Officer | Option exercise | Restricted Stock Units | 4,062 | $0.00 | - | |
| Hunter C. Smith - Officer | Option exercise | Restricted Stock Units | 4,925 | $0.00 | - | |
| Hunter C. Smith - Officer | Option exercise | Restricted Stock Units | 6,600 | $0.00 | - | |
| Hunter C. Smith - Officer | Option exercise | Restricted Stock Units | 10,413 | $0.00 | - | |
| Joseph Shulman - Officer | Option exercise | Common Stock | 16,968 | - | - | |
| Joseph Shulman - Officer | Tax withholding / forfeiture | Common Stock | 6,507 | $108.99 | $709K | |
| Joseph Shulman - Officer | Option exercise | Restricted Stock Units | 2,656 | $0.00 | - | |
| Joseph Shulman - Officer | Option exercise | Restricted Stock Units | 3,937 | $0.00 | - | |
| Joseph Shulman - Officer | Option exercise | Restricted Stock Units | 4,125 | $0.00 | - | |
| Joseph Shulman - Officer | Option exercise | Restricted Stock Units | 6,250 | $0.00 | - | |
| David P. Meeker - Officer | Option exercise | Common Stock | 68,713 | - | - | |
| David P. Meeker - Officer | Tax withholding / forfeiture | Common Stock | 31,522 | $108.99 | $3.44M | |
| David P. Meeker - Officer | Option exercise | Restricted Stock Units | 14,125 | $0.00 | - | |
| David P. Meeker - Officer | Option exercise | Restricted Stock Units | 21,250 | $0.00 | - | |
| David P. Meeker - Officer | Option exercise | Restricted Stock Units | 33,338 | $0.00 | - | |
| Jennifer Kayden Lee - Officer | Option exercise | Common Stock | 22,612 | - | - | |
| Jennifer Kayden Lee - Officer | Tax withholding / forfeiture | Common Stock | 9,237 | $108.99 | $1.01M | |
| Jennifer Kayden Lee - Officer | Option exercise | Restricted Stock Units | 3,437 | $0.00 | - | |
| Jennifer Kayden Lee - Officer | Option exercise | Restricted Stock Units | 4,512 | $0.00 | - | |
| Jennifer Kayden Lee - Officer | Option exercise | Restricted Stock Units | 5,500 | $0.00 | - | |
| Jennifer Kayden Lee - Officer | Option exercise | Restricted Stock Units | 9,163 | $0.00 | - | |
| Christopher Paul German - Officer | Option exercise | Common Stock | 3,613 | - | - | |
| Christopher Paul German - Officer | Tax withholding / forfeiture | Common Stock | 1,138 | $108.99 | $124K | |
| Christopher Paul German - Officer | Option exercise | Restricted Stock Units | 1,806 | $0.00 | - | |
| Christopher Paul German - Officer | Option exercise | Restricted Stock Units | 1,807 | $0.00 | - | |
| Alastair Garfield - Officer | Option exercise | Common Stock | 6,663 | - | - | |
| Alastair Garfield - Officer | Tax withholding / forfeiture | Common Stock | 2,026 | $108.99 | $221K | |
| Alastair Garfield - Officer | Option exercise | Restricted Stock Units | 6,663 | $0.00 | - | |
| Pamela J. Cramer - Officer | Option exercise | Common Stock | 13,293 | - | - | |
| Pamela J. Cramer - Officer | Tax withholding / forfeiture | Common Stock | 4,731 | $108.99 | $516K | |
| Pamela J. Cramer - Officer | Option exercise | Restricted Stock Units | 2,343 | $0.00 | - | |
| Pamela J. Cramer - Officer | Option exercise | Restricted Stock Units | 2,650 | $0.00 | - | |
| Pamela J. Cramer - Officer | Option exercise | Restricted Stock Units | 3,300 | $0.00 | - | |
| Pamela J. Cramer - Officer | Option exercise | Restricted Stock Units | 5,000 | $0.00 | - | |
| Pamela J. Cramer - Officer | Option exercise | Common Stock | 3,350 | $27.35 | $92K | |
| Pamela J. Cramer - Officer | Open-market sale | Common Stock | 3,350 | $105.00 | $352K | |
| Pamela J. Cramer - Officer | Option exercise | Stock Options (Right to Buy) | 3,350 | $0.00 | - | |
| Pamela J. Cramer - Officer | Option exercise | Stock Options (Right to Buy) | 10,546 | $0.00 | - | |
| Pamela J. Cramer - Officer | Option exercise | Stock Options (Right to Buy) | 3,515 | $0.00 | - | |
| Pamela J. Cramer - Officer | Option exercise | Common Stock | 8,805 | $19.02 | $167K | |
| Pamela J. Cramer - Officer | Option exercise | Common Stock | 10,546 | $6.80 | $72K | |
| Pamela J. Cramer - Officer | Option exercise | Common Stock | 3,515 | $6.80 | $24K | |
| Pamela J. Cramer - Officer | Open-market sale | Common Stock | 19,351 | $98.82 | $1.91M | |
| Pamela J. Cramer - Officer | Open-market sale | Common Stock | 3,515 | $100.00 | $352K | |
| Pamela J. Cramer - Officer | Option exercise | Stock Options (Right to Buy) | 8,805 | $0.00 | - | |
| Joseph Shulman - Officer | Option exercise | Stock Options (Right to Buy) | 9,748 | $0.00 | - | |
| Joseph Shulman - Officer | Option exercise | Common Stock | 9,748 | $30.66 | $299K | |
| Joseph Shulman - Officer | Open-market sale | Common Stock | 9,748 | $115.24 | $1.12M | |
| Joseph Shulman - Officer | Open-market sale | Common Stock | 2,815 | $115.01 | $324K | |
| Joseph Shulman - Officer | Option exercise | Stock Options (Right to Buy) | 2,094 | $0.00 | - | |
| Joseph Shulman - Officer | Option exercise | Stock Options (Right to Buy) | 721 | $0.00 | - | |
| Joseph Shulman - Officer | Option exercise | Common Stock | 2,094 | $27.35 | $57K | |
| Joseph Shulman - Officer | Option exercise | Common Stock | 721 | $30.66 | $22K | |
| Joseph Shulman - Officer | Option exercise | Stock Options (Right to Buy) | 2,093 | $0.00 | - | |
| Joseph Shulman - Officer | Option exercise | Stock Options (Right to Buy) | 12,344 | $0.00 | - | |
| Joseph Shulman - Officer | Option exercise | Common Stock | 2,093 | $27.35 | $57K | |
| Joseph Shulman - Officer | Option exercise | Common Stock | 12,344 | $30.66 | $378K | |
| Joseph Shulman - Officer | Open-market sale | Common Stock | 2,693 | $110.95 | $299K | |
| Joseph Shulman - Officer | Open-market sale | Common Stock | 8,332 | $112.06 | $934K | |
| Joseph Shulman - Officer | Open-market sale | Common Stock | 3,412 | $112.81 | $385K | |
| Joseph Shulman - Officer | Option exercise | Common Stock | 2,094 | $27.35 | $57K | |
| Joseph Shulman - Officer | Option exercise | Common Stock | 14,687 | $30.66 | $450K | |
| Joseph Shulman - Officer | Open-market sale | Common Stock | 16,781 | $105.30 | $1.77M | |
| Joseph Shulman - Officer | Option exercise | Stock Options (Right to Buy) | 2,094 | $0.00 | - | |
| Joseph Shulman - Officer | Option exercise | Stock Options (Right to Buy) | 14,687 | $0.00 | - | |
| Joseph Shulman - Officer | Option exercise | Common Stock | 4,188 | $27.35 | $115K | |
| Joseph Shulman - Officer | Open-market sale | Common Stock | 4,188 | $100.07 | $419K | |
| Joseph Shulman - Officer | Option exercise | Stock Options (Right to Buy) | 4,188 | $0.00 | - | |
| Hunter C. Smith - Officer | Option exercise | Common Stock | 24,611 | $6.88 | $169K | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 24,611 | $96.33 | $2.37M | |
| Hunter C. Smith - Officer | Option exercise | Common Stock | 3,477 | $6.88 | $24K | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 3,477 | $96.00 | $334K | |
| Hunter C. Smith - Officer | Option exercise | Stock Options (Right to Buy) | 24,611 | $0.00 | - | |
| Hunter C. Smith - Officer | Option exercise | Stock Options (Right to Buy) | 3,477 | $0.00 | - | |
| Christopher Paul German - Officer | Option exercise | Common Stock | 1,000 | $17.97 | $18K | |
| Christopher Paul German - Officer | Option exercise | Common Stock | 500 | $49.23 | $25K | |
| Christopher Paul German - Officer | Open-market sale | Common Stock | 1,500 | $95.00 | $143K | |
| Christopher Paul German - Officer | Option exercise | Stock Options (Right to Buy) | 1,000 | $0.00 | - | |
| Christopher Paul German - Officer | Option exercise | Stock Options (Right to Buy) | 500 | $0.00 | - | |
| Joseph Shulman - Officer | Option exercise | Common Stock | 3,984 | $6.80 | $27K | |
| Joseph Shulman - Officer | Open-market sale | Common Stock | 3,984 | $90.08 | $359K | |
| Joseph Shulman - Officer | Option exercise | Stock Options (Right to Buy) | 3,984 | $0.00 | - | |
| Pamela J. Cramer - Officer | Option exercise | Common Stock | 3,125 | - | - | |
| Pamela J. Cramer - Officer | Open-market sale | Common Stock | 1,520 | $85.93 | $131K | |
| Pamela J. Cramer - Officer | Option exercise | Restricted Stock Units | 3,125 | $0.00 | - | |
| Christopher Paul German - Officer | Option exercise | Common Stock | 2,000 | $17.97 | $36K | |
| Christopher Paul German - Officer | Option exercise | Common Stock | 850 | $49.23 | $42K | |
| Christopher Paul German - Officer | Open-market sale | Common Stock | 1,967 | $76.75 | $151K | |
| Christopher Paul German - Officer | Open-market sale | Common Stock | 1,850 | $85.00 | $157K | |
| Christopher Paul German - Officer | Option exercise | Stock Options (Right to Buy) | 2,000 | $0.00 | - | |
| Christopher Paul German - Officer | Option exercise | Stock Options (Right to Buy) | 850 | $0.00 | - | |
| Pamela J. Cramer - Officer | Option exercise | Common Stock | 10,547 | $6.80 | $72K | |
| Pamela J. Cramer - Officer | Option exercise | Common Stock | 5,025 | $27.35 | $137K | |
| Pamela J. Cramer - Officer | Open-market sale | Common Stock | 4,225 | $75.55 | $319K | |
| Pamela J. Cramer - Officer | Open-market sale | Common Stock | 7,831 | $76.69 | $601K | |
| Pamela J. Cramer - Officer | Open-market sale | Common Stock | 3,516 | $80.00 | $281K | |
| Pamela J. Cramer - Officer | Option exercise | Stock Options (Right to Buy) | 10,547 | $0.00 | - | |
| Pamela J. Cramer - Officer | Option exercise | Stock Options (Right to Buy) | 5,025 | $0.00 | - | |
| Joseph Shulman - Officer | Option exercise | Common Stock | 7,969 | $6.80 | $54K | |
| Joseph Shulman - Officer | Open-market sale | Common Stock | 3,984 | $75.56 | $301K | |
| Joseph Shulman - Officer | Open-market sale | Common Stock | 3,985 | $80.00 | $319K | |
| Joseph Shulman - Officer | Option exercise | Stock Options (Right to Buy) | 7,969 | $0.00 | - | |
| Hunter C. Smith - Officer | Option exercise | Common Stock | 42,120 | $6.88 | $290K | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 17,113 | $75.38 | $1.29M | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 1,607 | $76.17 | $122K | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 23,400 | $84.50 | $1.98M | |
| Hunter C. Smith - Officer | Option exercise | Stock Options (Right to Buy) | 42,120 | $0.00 | - | |
| Hunter C. Smith - Officer | Option exercise | Common Stock | 6,986 | $6.88 | $48K | |
| Hunter C. Smith - Officer | Option exercise | Stock Options (Right to Buy) | 6,986 | $0.00 | - | |
| Alastair Garfield - Officer | Option exercise | Common Stock | 4,445 | - | - | |
| Alastair Garfield - Officer | Open-market sale | Common Stock | 1,313 | $64.81 | $85K | |
| Alastair Garfield - Officer | Open-market sale | Common Stock | 6 | $64.60 | $388 | |
| Alastair Garfield - Officer | Option exercise | Restricted Stock Units | 4,445 | $0.00 | - | |
| Jennifer L. Good - Director | Grant or award | Stock Option (right to buy) | 7,037 | $0.00 | - | |
| Jennifer L. Good - Director | Grant or award | Restricted Stock Units | 4,712 | $0.00 | - | |
| David W. J. McGirr - Director | Grant or award | Stock Option (right to buy) | 7,037 | $0.00 | - | |
| David W. J. McGirr - Director | Grant or award | Restricted Stock Units | 4,712 | $0.00 | - |
A Form 144 is notice of an INTENDED sale, not a completed one. It often precedes the Form 4 that reports the trade actually happening.
| Filed | Filer | Relationship | Shares | Market value | Notice |
|---|---|---|---|---|---|
| JOSEPH J SHULMAN | Officer | 5,079 | $597K | View on EDGAR | |
| ALASTAIR GARFIELD | Officer | 7,763 | $913K | View on EDGAR | |
| Jennifer Kayden Lee | Officer | 75,834 | $8.92M | View on EDGAR |
RHYTHM PHARMACEUTICALS, INC. (RYTM) had 12 insider filings in the last 90 days, with the most recent on 2026-08-18. The full record for RYTM runs to 67 Form 4 filings, the earliest from 2024-11-08. InsiderAlpha tracks every Form 4, Form 144, and 8-K filing in real time.
No insider purchases of RYTM were filed in the last 90 days.
13 insider sales of RYTM were filed in the last 90 days, totaling $20.75M.
This page tracks RYTM Form 4 insider transactions, Form 144 sale notices, and 8-K material event disclosures in one timeline. Annual 10-K and quarterly 10-Q reports live on the company's SEC EDGAR page.
Create a free InsiderAlpha account and press Watch on this page to add RYTM to your watchlist. A free account also opens the full scored daily plan with every past day and 3 months of price history. No card is required. Sign up at https://insideralpha.ai/register.
Every Form 4 below links to the original document on SEC EDGAR, so the numbers on this page can be checked against the filing they came from.
Real-time Form 4 alerts, AI-scored daily trade ideas and 10b5-1 plan flags.
