RHYTHM PHARMACEUTICALS, INC. (RYTM)
$107.17-$5.36 (-4.76%) Today
Yann Mazabraud - OfficerYann Mazabraud - OfficerRhythm Pharmaceuticals Inc is a commercial-stage biopharmaceutical company engaged in the development and commercialization of therapies for patients with rare neuroendocrine diseases. The company is focused on advancing its melanocortin-4 receptor (MC4R) agonists, including its main asset, IMCIVREE (setmelanotide), as a precision medicine designed to treat hyperphagia and severe obesity caused by rare MC4R pathway diseases. In addition, it has two early-stage investigational MC4R agonists in clinical development, RM-718 and bivamelagon, designed not to cause hyperpigmentation. The company is also focused on advancing potential candidates for congenital hyperinsulinism. It currently operates in two business segments: the United States, which generates maximum revenue, and International.
| Form 4 transaction type | Transactions | Shares | Total value |
|---|---|---|---|
| Open-market sale | 13 | 182,676 | $20.75M |
| Grant or award | 12 | 105,075 | |
| Option exercise | 22 | 340,510 | |
| Tax withholding / forfeiture | 1 | 2,150 |
Dollar totals are shown for open-market purchases and sales only. Grants, option exercises, gifts and tax withholding are reported by share count because they are not trades at a market price.
67 Form 4 filings on record, the earliest from Nov 8, 2024, newest first. Filing history page 1 of 3.
| Date | Insider | Transaction | Security | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Manher Joshi - Officer | Grant or award | Stock Options (Right to Buy) | 50,000 | $0.00 | - | |
| Manher Joshi - Officer | Grant or award | Restricted Stock Units | 25,000 | $0.00 | - | |
| Joseph Shulman - Officer | Option exercise | Common Stock | 2,024 | $6.80 | $14K | |
| Joseph Shulman - Officer | Open-market sale | Common Stock | 5,079 | $119.75 | $608K | |
| Joseph Shulman - Officer | Option exercise | Stock Options (Right to Buy) | 2,024 | $0.00 | - | |
| Alastair Garfield - Officer | Open-market sale | Common Stock | 2,007 | $116.11 | $233K | |
| Alastair Garfield - Officer | Open-market sale | Common Stock | 1,556 | $117.08 | $182K | |
| Alastair Garfield - Officer | Open-market sale | Common Stock | 3,400 | $118.28 | $402K | |
| Alastair Garfield - Officer | Open-market sale | Common Stock | 800 | $119.17 | $95K | |
| Jennifer Kayden Lee - Officer | Option exercise | Common Stock | 35,000 | $24.29 | $850K | |
| Jennifer Kayden Lee - Officer | Option exercise | Common Stock | 21,601 | $6.80 | $147K | |
| Jennifer Kayden Lee - Officer | Open-market sale | Common Stock | 75,834 | $117.38 | $8.90M | |
| Jennifer Kayden Lee - Officer | Option exercise | Stock Options (Right to Buy) | 35,000 | $0.00 | - | |
| Jennifer Kayden Lee - Officer | Option exercise | Stock Options (Right to Buy) | 21,601 | $0.00 | - | |
| Yann Mazabraud - Officer | Option exercise | Common Stock | 46,625 | $6.80 | $317K | |
| Yann Mazabraud - Officer | Open-market sale | Common Stock | 2,300 | $111.80 | $257K | |
| Yann Mazabraud - Officer | Open-market sale | Common Stock | 1,000 | $112.86 | $113K | |
| Yann Mazabraud - Officer | Open-market sale | Common Stock | 3,605 | $114.70 | $413K | |
| Yann Mazabraud - Officer | Open-market sale | Common Stock | 14,568 | $115.43 | $1.68M | |
| Yann Mazabraud - Officer | Open-market sale | Common Stock | 18,208 | $116.49 | $2.12M | |
| Yann Mazabraud - Officer | Open-market sale | Common Stock | 17,319 | $117.47 | $2.03M | |
| Yann Mazabraud - Officer | Option exercise | Stock Options (Right to Buy) | 46,625 | $0.00 | - | |
| Alastair Garfield - Officer | Option exercise | Common Stock | 4,445 | - | - | |
| Alastair Garfield - Officer | Tax withholding / forfeiture | Common Stock | 2,150 | $110.41 | $237K | |
| Alastair Garfield - Officer | Option exercise | Restricted Stock Units | 4,445 | $0.00 | - | |
| Christophe Jean - Director | Grant or award | Restricted Stock Units | 2,324 | $0.00 | - | |
| Christophe Jean - Director | Option exercise | Common Stock | 4,712 | - | - | |
| Christophe Jean - Director | Option exercise | Restricted Stock Units | 4,712 | $0.00 | - | |
| Christophe Jean - Director | Grant or award | Stock Option (right to buy) | 3,691 | $0.00 | - | |
| David W. J. McGirr - Director | Option exercise | Restricted Stock Units | 4,712 | $0.00 | - | |
| David W. J. McGirr - Director | Grant or award | Stock Option (right to buy) | 3,691 | $0.00 | - | |
| David W. J. McGirr - Director | Grant or award | Restricted Stock Units | 2,324 | $0.00 | - | |
| David W. J. McGirr - Director | Option exercise | Common Stock | 4,712 | - | - | |
| Lynn A. Tetrault - Director | Option exercise | Restricted Stock Units | 4,712 | $0.00 | - | |
| Lynn A. Tetrault - Director | Grant or award | Stock Option (right to buy) | 3,691 | $0.00 | - | |
| Lynn A. Tetrault - Director | Grant or award | Restricted Stock Units | 2,324 | $0.00 | - | |
| Lynn A. Tetrault - Director | Option exercise | Common Stock | 4,712 | - | - | |
| Stuart A. Arbuckle - Director | Option exercise | Common Stock | 4,712 | - | - | |
| Stuart A. Arbuckle - Director | Option exercise | Restricted Stock Units | 4,712 | $0.00 | - | |
| Stuart A. Arbuckle - Director | Grant or award | Stock Option (right to buy) | 3,691 | $0.00 | - | |
| Stuart A. Arbuckle - Director | Grant or award | Restricted Stock Units | 2,324 | $0.00 | - | |
| Jennifer L. Good - Director | Option exercise | Restricted Stock Units | 4,712 | $0.00 | - | |
| Jennifer L. Good - Director | Grant or award | Stock Option (right to buy) | 3,691 | $0.00 | - | |
| Jennifer L. Good - Director | Grant or award | Restricted Stock Units | 2,324 | $0.00 | - | |
| Jennifer L. Good - Director | Option exercise | Common Stock | 4,712 | - | - | |
| Lynn A. Tetrault - Director | Option exercise | Stock Option (right to buy) | 37,000 | $0.00 | - | |
| Lynn A. Tetrault - Director | Option exercise | Common Stock | 37,000 | $28.27 | $1.05M | |
| Lynn A. Tetrault - Director | Open-market sale | Common Stock | 37,000 | $100.32 | $3.71M | |
| Hunter C. Smith - Officer | Option exercise | Common Stock | 3,000 | $17.87 | $54K | |
| Hunter C. Smith - Officer | Option exercise | Stock Options (Right to Buy) | 3,000 | $0.00 | - | |
| Christopher Paul German - Officer | Option exercise | Common Stock | 1,349 | $49.23 | $66K | |
| Christopher Paul German - Officer | Option exercise | Common Stock | 1,406 | $17.97 | $25K | |
| Christopher Paul German - Officer | Open-market sale | Common Stock | 4,643 | $92.21 | $428K | |
| Christopher Paul German - Officer | Option exercise | Common Stock | 1,687 | $56.69 | $96K | |
| Christopher Paul German - Officer | Option exercise | Stock Options (Right to Buy) | 1,687 | $0.00 | - | |
| Christopher Paul German - Officer | Option exercise | Stock Options (Right to Buy) | 1,349 | $0.00 | - | |
| Christopher Paul German - Officer | Option exercise | Stock Options (Right to Buy) | 1,406 | $0.00 | - | |
| Yann Mazabraud - Officer | Option exercise | Common Stock | 12,875 | - | - | |
| Yann Mazabraud - Officer | Option exercise | Restricted Stock Units | 10,375 | $0.00 | - | |
| Yann Mazabraud - Officer | Option exercise | Restricted Stock Units | 2,500 | $0.00 | - | |
| Kimberly J. Popovits - Director | Grant or award | Restricted Stock Units | 6,808 | $0.00 | - | |
| Kimberly J. Popovits - Director | Grant or award | Stock Options (Right to Buy) | 10,257 | $0.00 | - | |
| Edward T. Mathers | Other | Common Stock | 4,199 | $0.00 | - | |
| Christopher Paul German - Officer | Option exercise | Common Stock | 1,500 | $17.97 | $27K | |
| Christopher Paul German - Officer | Open-market sale | Common Stock | 5,614 | $89.56 | $503K | |
| Christopher Paul German - Officer | Option exercise | Stock Options (Right to Buy) | 1,500 | $0.00 | - | |
| Yann Mazabraud - Officer | Grant or award | Stock Options (Right to Buy) | 35,000 | $0.00 | - | |
| Edward T. Mathers | Other | Common Stock | 4,198 | $0.00 | - | |
| Christopher Paul German - Officer | Option exercise | Restricted Stock Units | 1,162 | $0.00 | - | |
| Christopher Paul German - Officer | Option exercise | Common Stock | 1,162 | - | - | |
| Christopher Paul German - Officer | Tax withholding / forfeiture | Common Stock | 342 | $94.94 | $32K | |
| Hunter C. Smith - Officer | Option exercise | Common Stock | 6,099 | $6.80 | $41K | |
| Hunter C. Smith - Officer | Option exercise | Stock Options (Right to Buy) | 6,099 | $0.00 | - | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 1,200 | $99.42 | $119K | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 200 | $103.84 | $21K | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 200 | $100.52 | $20K | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 900 | $101.70 | $92K | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 1,069 | $103.00 | $110K | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 1,308 | $100.27 | $131K | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 1,692 | $100.92 | $171K | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 800 | $102.10 | $82K | |
| Hunter C. Smith - Officer | Open-market sale | Common Stock | 585 | $103.28 | $60K | |
| Yann Mazabraud - Officer | Option exercise | Common Stock | 10,000 | - | - | |
| Yann Mazabraud - Officer | Option exercise | Restricted Stock Units | 10,000 | $0.00 | - | |
| Joseph Shulman - Officer | Grant or award | Restricted Stock Units | 15,000 | $0.00 | - | |
| Joseph Shulman - Officer | Grant or award | Stock Options (Right to Buy) | 22,500 | $0.00 | - | |
| David P. Meeker - Officer | Grant or award | Restricted Stock Units | 71,900 | $0.00 | - | |
| David P. Meeker - Officer | Grant or award | Stock Options (Right to Buy) | 107,850 | $0.00 | - | |
| Yann Mazabraud - Officer | Grant or award | Restricted Stock Units | 23,350 | $0.00 | - | |
| Jennifer Kayden Lee - Officer | Grant or award | Restricted Stock Units | 21,650 | $0.00 | - | |
| Jennifer Kayden Lee - Officer | Grant or award | Stock Options (Right to Buy) | 32,500 | $0.00 | - | |
| Christopher Paul German - Officer | Grant or award | Restricted Stock Units | 5,215 | $0.00 | - | |
| Alastair Garfield - Officer | Grant or award | Restricted Stock Units | 16,650 | $0.00 | - | |
| Alastair Garfield - Officer | Grant or award | Stock Options (Right to Buy) | 25,000 | $0.00 | - |
A Form 144 is notice of an INTENDED sale, not a completed one. It often precedes the Form 4 that reports the trade actually happening.
| Filed | Filer | Relationship | Shares | Market value | Notice |
|---|---|---|---|---|---|
| JOSEPH J SHULMAN | Officer | 5,079 | $597K | View on EDGAR | |
| ALASTAIR GARFIELD | Officer | 7,763 | $913K | View on EDGAR | |
| Jennifer Kayden Lee | Officer | 75,834 | $8.92M | View on EDGAR |
RHYTHM PHARMACEUTICALS, INC. (RYTM) had 12 insider filings in the last 90 days, with the most recent on 2026-08-18. The full record for RYTM runs to 67 Form 4 filings, the earliest from 2024-11-08. InsiderAlpha tracks every Form 4, Form 144, and 8-K filing in real time.
No insider purchases of RYTM were filed in the last 90 days.
13 insider sales of RYTM were filed in the last 90 days, totaling $20.75M.
This page tracks RYTM Form 4 insider transactions, Form 144 sale notices, and 8-K material event disclosures in one timeline. Annual 10-K and quarterly 10-Q reports live on the company's SEC EDGAR page.
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Every Form 4 below links to the original document on SEC EDGAR, so the numbers on this page can be checked against the filing they came from.
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