PepGen Inc is a clinical-stage biotechnology company advancing the next generation of oligonucleotide therapeutics to transform the treatment of severe neuromuscular and neurologic diseases. The company has developed its Enhanced Delivery Oligonucleotide platform to improve the uptake and activity of conjugated oligonucleotide therapeutics. Its EDO peptides are engineered to optimize tissue penetration, cellular uptake, and nuclear delivery, and in preclinical studies, it is observed that their ability to transport oligonucleotides into a broad range of target tissues, including smooth, skeletal, and cardiac muscle, and the central nervous system. Its pipeline products are: PGN-EDO51, PGN-EDODM1, and others.
| Form 4 transaction type | Transactions | Shares | Total value |
|---|---|---|---|
| Grant or award | 8 | 272,000 |
Dollar totals are shown for open-market purchases and sales only. Grants, option exercises, gifts and tax withholding are reported by share count because they are not trades at a market price.
23 Form 4 filings on record, the earliest from Jun 4, 2025, newest first.
| Date | Insider | Transaction | Security | Shares | Price | Value |
|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | Grant or award | Stock Option (Right to Buy) | 34,000 | $0.00 | - | |
| Lisa Wyman - Director | Grant or award | Stock Option (Right to Buy) | 34,000 | $0.00 | - | |
| Joshua Resnick - Director | Grant or award | Stock Option (Right to Buy) | 34,000 | $0.00 | - | |
| Grant or award | Stock Option (Right to Buy) | 34,000 | $0.00 | - | ||
| Mitchell H. Finer - Director | Grant or award | Stock Option (Right to Buy) | 34,000 | $0.00 | - | |
| Habib J. Dable - Director | Grant or award | Stock Option (Right to Buy) | 34,000 | $0.00 | - | |
| Heidi Henson - Director | Grant or award | Stock Option (Right to Buy) | 34,000 | $0.00 | - | |
| Laurie Keating - Director | Grant or award | Stock Option (Right to Buy) | 34,000 | $0.00 | - | |
| Kasra Kasraian - Officer | Open-market sale | Common Stock | 1,233 | $1.41 | $2K | |
| Paul Streck - Officer | Open-market sale | Common Stock | 1,832 | $6.23 | $11K | |
| Paul Streck - Officer | Open-market sale | Common Stock | 47 | $6.29 | $296 | |
| Noel Donnelly - Officer | Open-market sale | Common Stock | 2,032 | $6.23 | $13K | |
| Noel Donnelly - Officer | Open-market sale | Common Stock | 52 | $6.33 | $329 | |
| James G. McArthur - Officer | Open-market sale | Common Stock | 5,144 | $6.23 | $32K | |
| James G. McArthur - Officer | Open-market sale | Common Stock | 131 | $6.33 | $829 | |
| Joseph Vittiglio - Officer | Grant or award | Common Stock | 30,717 | $0.00 | - | |
| Joseph Vittiglio - Officer | Grant or award | Stock Option (Right to Buy) | 120,000 | $0.00 | - | |
| Kasra Kasraian - Officer | Grant or award | Common Stock | 34,557 | $0.00 | - | |
| Kasra Kasraian - Officer | Grant or award | Stock Option (Right to Buy) | 135,000 | $0.00 | - | |
| Paul Streck - Officer | Grant or award | Common Stock | 50,300 | $0.00 | - | |
| Paul Streck - Officer | Grant or award | Stock Option (Right to Buy) | 196,500 | $0.00 | - | |
| Noel Donnelly - Officer | Grant or award | Common Stock | 76,793 | $0.00 | - | |
| Noel Donnelly - Officer | Grant or award | Stock Option (Right to Buy) | 300,000 | $0.00 | - | |
| James G. McArthur - Officer | Grant or award | Common Stock | 187,688 | $0.00 | - | |
| James G. McArthur - Officer | Grant or award | Stock Option (Right to Buy) | 731,250 | $0.00 | - | |
| Paul Streck - Officer | Derivative | Stock Option (Right to Buy) | 202,816 | $0.00 | - | |
| Paul Streck - Officer | Grant or award | Stock Option (Right to Buy) | 202,816 | $0.00 | - | |
| Paul Streck - Officer | Derivative | Stock Option (Right to Buy) | 40,000 | $0.00 | - | |
| Paul Streck - Officer | Grant or award | Stock Option (Right to Buy) | 40,000 | $0.00 | - | |
| James G. McArthur - Officer | Derivative | Stock Option (Right to Buy) | 352,705 | $0.00 | - | |
| James G. McArthur - Officer | Grant or award | Stock Option (Right to Buy) | 352,705 | $0.00 | - | |
| James G. McArthur - Officer | Derivative | Stock Option (Right to Buy) | 40,815 | $0.00 | - | |
| James G. McArthur - Officer | Grant or award | Stock Option (Right to Buy) | 40,815 | $0.00 | - | |
| James G. McArthur - Officer | Derivative | Stock Option (Right to Buy) | 40,815 | $0.00 | - | |
| James G. McArthur - Officer | Grant or award | Stock Option (Right to Buy) | 40,815 | $0.00 | - | |
| James G. McArthur - Officer | Derivative | Stock Option (Right to Buy) | 40,815 | $0.00 | - | |
| James G. McArthur - Officer | Grant or award | Stock Option (Right to Buy) | 40,815 | $0.00 | - | |
| James G. McArthur - Officer | Derivative | Stock Option (Right to Buy) | 466,095 | $0.00 | - | |
| James G. McArthur - Officer | Grant or award | Stock Option (Right to Buy) | 466,095 | $0.00 | - | |
| James G. McArthur - Officer | Derivative | Stock Option (Right to Buy) | 275,000 | $0.00 | - | |
| James G. McArthur - Officer | Grant or award | Stock Option (Right to Buy) | 275,000 | $0.00 | - | |
| James G. McArthur - Officer | Derivative | Stock Option (Right to Buy) | 300,000 | $0.00 | - | |
| James G. McArthur - Officer | Grant or award | Stock Option (Right to Buy) | 300,000 | $0.00 | - | |
| Noel Donnelly - Officer | Derivative | Stock Option (Right to Buy) | 203,339 | $0.00 | - | |
| Noel Donnelly - Officer | Grant or award | Stock Option (Right to Buy) | 203,339 | $0.00 | - | |
| Noel Donnelly - Officer | Derivative | Stock Option (Right to Buy) | 169,037 | $0.00 | - | |
| Noel Donnelly - Officer | Grant or award | Stock Option (Right to Buy) | 169,037 | $0.00 | - | |
| Noel Donnelly - Officer | Derivative | Stock Option (Right to Buy) | 144,000 | $0.00 | - | |
| Noel Donnelly - Officer | Grant or award | Stock Option (Right to Buy) | 144,000 | $0.00 | - | |
| Noel Donnelly - Officer | Derivative | Stock Option (Right to Buy) | 144,000 | $0.00 | - | |
| Noel Donnelly - Officer | Grant or award | Stock Option (Right to Buy) | 144,000 | $0.00 | - | |
| Oxford Science Enterprises plc | Open-market purchase | Common Stock | 200,000 | $3.20 | $640K | |
| RA CAPITAL MANAGEMENT, L.P. | Open-market purchase | Common Stock | 9,375,000 | $3.20 | $30.00M | |
| Heidi Henson - Director | Grant or award | Stock Option (Right to Buy) | 16,000 | $0.00 | - |
PepGen Inc. (PEPG) had 8 insider filings in the last 90 days, with the most recent on 2026-06-22. The full record for PEPG runs to 23 Form 4 filings, the earliest from 2025-06-04. InsiderAlpha tracks every Form 4, Form 144, and 8-K filing in real time.
No insider purchases of PEPG were filed in the last 90 days. 2 purchases are on record for this company.
No insider sales of PEPG were filed in the last 90 days. 7 sales are on record for this company.
This page tracks PEPG Form 4 insider transactions, Form 144 sale notices, and 8-K material event disclosures in one timeline. Annual 10-K and quarterly 10-Q reports live on the company's SEC EDGAR page.
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Every Form 4 below links to the original document on SEC EDGAR, so the numbers on this page can be checked against the filing they came from.
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