Summary
Updated Aug 31, 2026
Opaleye Management Inc. is 10% Owner of Grace Therapeutics, Inc. (GRCE). 68 SEC Form 4 filings on record going back to 2024, most recently on 19 August 2026. Most recent open-market trade: bought $24K of GRCE on 19 August 2026. Lifetime open-market purchases: $22.40M. Lifetime open-market sales: $21.84M. Historical track record: 5/5 stars across 93 tracked purchases.
Recent Transactions
20Every recent SEC Form 4 transaction Opaleye Management Inc. has reported, most recent first.
Track Record
InsiderAlpha computes a forward-return-based score for every insider with enough Form 4 purchase history. The metrics below reflect realized performance after each tracked open-market purchase.
| Metric | Value |
|---|---|
| InsiderAlpha rating | ★★★★★ (5/5) |
| Total purchases tracked | 93 |
| Purchases with forward-return data | 87 |
| 30-day win rate | 78% |
| 90-day win rate | 80% |
| Avg 5-day return | +3.16% |
| Avg 30-day return | +15.96% |
| Avg 90-day return | +35.40% |
| Best 30-day return | +68.89% |
Trading Pattern
InsiderAlpha's records for Opaleye Management Inc. go back to 2024: 68 primary Form 4 filings, an average of 22.7 per year. The typical open-market purchase is $191K (117 buys totaling $22.40M). The largest single buy on record is $5.48M of CDXS in 2025. Sales side: 37 recorded sales totaling $21.84M, so the filing history runs buy-heavy by dollar value. No transaction on record carries a Rule 10b5-1 flag - the filings look discretionary rather than pre-scheduled, which makes their timing more informative as a signal.
Other Insiders Active in the Same Stocks
Insiders who reported open-market trades in the last 12 months at the companies Opaleye Management Inc. files at. Multiple unrelated insiders buying the same stock within a short window, cluster buying, has historically been one of the strongest Form 4 signals.
- Robert James Wills - $96K of ACOG open-market activity in the last 12 months
- Lauren D'Angelo - $20K of ACOG open-market activity in the last 12 months
More Notable Insiders
Other corporate insiders with significant SEC Form 4 track records on InsiderAlpha:
Frequently Asked Questions
What is Opaleye Management Inc.?
Opaleye Management Inc. is an investment firm, tracked as 10% Owner of Grace Therapeutics, Inc. (GRCE). InsiderAlpha holds 68 primary Form 4 filings for it, the earliest from 2024, updated as new SEC EDGAR filings are processed.
How many SEC Form 4 filings has Opaleye Management Inc. submitted recently?
15 primary Form 4 filings in the last 90 days, covering 4 companies.
Has Opaleye Management Inc. been buying or selling stock?
Recorded transactions: 117 open-market purchases ($22.40M) and 37 open-market sales ($21.84M) across all tracked filings.
How accurate is Opaleye Management Inc.'s historical track record?
Across 93 tracked purchases, Opaleye Management Inc. averaged +16.0% avg 30-day return with a 78% 30-day win rate. InsiderAlpha rates the track record at 5/5 stars.
Where can I see all of Opaleye Management Inc.'s SEC filings?
All Form 4 filings, transaction values, and 10b5-1 plan flags are listed on this page and updated in real time as new SEC EDGAR filings are processed.
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