Eton Pharmaceuticals, Inc. (ETON)

Data as of Oct 6, 2026, from SEC Form 4 filings.

Net insider selling (90d)Watch ETON

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Latest ETON insider trades

David Krempa - Officer
Open-market sale$229K
Oct 6, 2026
Paul V. Maier - Director
Open-market sale$2.13M
Aug 28, 2026

About Eton Pharmaceuticals, Inc. (ETON)

Eton Pharmaceuticals, Inc. is an SEC registrant, filing under CIK 0001710340, classified as pharmaceutical preparations. It is grouped with Health Care companies on this site.

Sector: Health Care

SEC filings for ETON on EDGAR

ETON Form 4 activity by transaction type, last 90 days

Form 4 transaction type	Transactions	Shares	Total value
Open-market sale	16	285,796	$15.98M
Grant or award	8	410,216
Option exercise	10	296,044

Dollar totals cover purchases and sales only (codes P and S). Grants, option exercises, gifts and tax withholding are counted in shares, because none of them is a trade at a market price.

ETON insider transactions (Form 4)

36 Form 4 filings on record, the earliest from Oct 4, 2024, newest first. Filing history page 1 of 2.

Date	Insider	Transaction	Security	Shares	Price	Value
Oct 2, 2026	David Krempa - Officer	Option exercise	Common Stock	10,522	-^{footnote F3}	-
Oct 6, 2026	David Krempa - Officer	Open-market sale	Common Stock	4,166	$55.07^{footnote F1,F2}	$229K
Oct 2, 2026	David Krempa - Officer	Option exercise	Restricted Stock Units	10,522	$0.00	-
Footnote F1 (price): The Reporting Person will provide upon request by the Securities and Exchange Commission staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased or sold at each separate price. Footnote F2 (price): The shares were sold in multiple trades at prices ranging from $54.915 to $55.135. The price reported above reflects the weighted average sales price. Footnote F3 (price): On October 2, 2024, the reporting person was granted 42,088 restricted stock units which vest in four equal annual installments beginning October 2, 2025.
Aug 28, 2026	Paul V. Maier - Director	Option exercise	Common Stock	50,000	$3.78	$189K
Aug 28, 2026	Paul V. Maier - Director	Open-market sale	Common Stock	36,387	$58.64^{footnote F1,F2}	$2.13M
Aug 28, 2026	Paul V. Maier - Director	Open-market sale	Common Stock	13,485	$60.21^{footnote F1,F4}	$812K
Aug 28, 2026	Paul V. Maier - Director	Open-market sale	Common Stock	128	$61.77^{footnote F1,F5}	$8K
Aug 28, 2026	Paul V. Maier - Director	Option exercise	Common Stock	12,500	$7.31	$91K
Aug 28, 2026	Paul V. Maier - Director	Option exercise	Employee Stock Option	50,000	$0.00	-
Aug 28, 2026	Paul V. Maier - Director	Option exercise	Employee Stock Option	12,500	$0.00	-
Footnote F1 (price): The Reporting Person will provide upon request by the Securities and Exchange Commission staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased or sold at each separate price. Footnote F2 (price): The shares were sold in multiple trades at prices ranging from $58.50 to $58.97. The price reported above reflects the weighted average sales price. Footnote F4 (price): The shares were sold in multiple trades at prices ranging from $60.00 to $61.00. The price reported above reflects the weighted average sales price. Footnote F5 (price): The shares were sold in multiple trades at prices ranging from $61.10 to $61.98. The price reported above reflects the weighted average sales price.
Aug 28, 2026	Paul V. Maier - Director	Option exercise	Common Stock	50,000	$3.78	$189K
Aug 28, 2026	Paul V. Maier - Director	Open-market sale	Common Stock	36,387	$58.64^{footnote F1,F2}	$2.13M
Aug 28, 2026	Paul V. Maier - Director	Open-market sale	Common Stock	13,485	$60.21^{footnote F1,F4}	$812K
Aug 28, 2026	Paul V. Maier - Director	Open-market sale	Common Stock	128	$61.77^{footnote F1,F5}	$8K
Aug 28, 2026	Paul V. Maier - Director	Option exercise	Employee Stock Option	50,000	$0.00	-
Footnote F1 (price): The Reporting Person will provide upon request by the Securities and Exchange Commission staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased or sold at each separate price. Footnote F2 (price): The shares were sold in multiple trades at prices ranging from $58.50 to $58.97. The price reported above reflects the weighted average sales price. Footnote F4 (price): The shares were sold in multiple trades at prices ranging from $60.00 to $61.00. The price reported above reflects the weighted average sales price. Footnote F5 (price): The shares were sold in multiple trades at prices ranging from $61.10 to $61.98. The price reported above reflects the weighted average sales price.
Aug 24, 2026	David Krempa - Officer	Option exercise	Common Stock	25,000	$7.31	$183K
Aug 24, 2026	David Krempa - Officer	Open-market sale	Common Stock	25,000	$65.07^{footnote F1,F2}	$1.63M
Aug 24, 2026	David Krempa - Officer	Option exercise	Employee Stock Option	25,000	$0.00	-
Footnote F1 (price): The Reporting Person will provide upon request by the Securities and Exchange Commission staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased or sold at each separate price. Footnote F2 (price): The shares were sold in multiple trades at prices ranging from $64.88 to $65.57. The price reported above reflects the weighted average sales price.
Aug 19, 2026	Sean Brynjelsen - Officer	Open-market sale	Common Stock	8,978	$62.65^{footnote F1,F2}	$562K
Aug 20, 2026	Sean Brynjelsen - Officer	Open-market sale	Common Stock	47,307	$60.17^{footnote F2,F3}	$2.85M
Aug 20, 2026	Sean Brynjelsen - Officer	Open-market sale	Common Stock	36,373	$61.11^{footnote F2,F4}	$2.22M
Aug 20, 2026	Sean Brynjelsen - Officer	Open-market sale	Common Stock	7,342	$62.12^{footnote F2,F5}	$456K
Footnote F1 (price): The shares were sold in multiple trades at prices ranging from $62.50 to $63.41. The price above reflects the weighted average sales price. Footnote F2 (price): The Reporting Person will provide upon request by the Securities and Exchange Commission staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price. Footnote F3 (price): The shares were sold in multiple trades at prices ranging from $59.59 to $60.59. The price above reflects the weighted average sales price. Footnote F4 (price): The shares were sold in multiple trades at prices ranging from $60.61 to $61.61. The price above reflects the weighted average sales price. Footnote F5 (price): The shares were sold in multiple trades at prices ranging from $61.63 to $62.52. The price above reflects the weighted average sales price.
Jul 31, 2026	Charles J. Casamento - Director	Grant or award	Common Stock	10,000	$0.00	-
Jul 31, 2026	Judith M. Matthews - Officer	Grant or award	Common Stock	32,246	$0.00	-
Jul 31, 2026	Ipek Erdogan-Trinkaus - Officer	Grant or award	Common Stock	80,000	$0.00	-
Jul 31, 2026	Sean Brynjelsen - Officer	Grant or award	Common Stock	128,985	$0.00	-
Jul 31, 2026	David Krempa - Officer	Grant or award	Common Stock	128,985	$0.00	-
Jul 31, 2026	Paul V. Maier - Director	Grant or award	Common Stock	10,000	$0.00	-
Jul 31, 2026	Norbert G. Riedel - Director	Grant or award	Common Stock	10,000	$0.00	-
Jul 31, 2026	Jennifer McKie Adams - Director	Grant or award	Common Stock	10,000	$0.00	-
Jul 14, 2026	Opaleye Management Inc. - 10% Owner	Open-market sale	Common Stock, par value $0.001 per share	15,000	$37.54	$563K
Jul 14, 2026	Opaleye Management Inc. - 10% Owner	Open-market sale	Common Stock, par value $0.001 per share	13,315	$37.54	$500K
Jul 14, 2026	Opaleye Management Inc. - 10% Owner	Open-market sale	Common Stock, par value $0.001 per share	15,000	$37.54^{footnote F3}	$563K
Jul 14, 2026	Opaleye Management Inc. - 10% Owner	Open-market sale	Common Stock, par value $0.001 per share	13,315	$37.54^{footnote F3}	$500K
Footnote F3 (price): The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $37.0152 to $37.9148 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the… Full note on SEC EDGAR
Jul 14, 2026	Sean Brynjelsen - Officer	Option exercise	Common Stock	200,000	$1.37	$274K
Jul 12, 2026	Sean Brynjelsen - Officer	Option exercise	Common Stock	27,500	-^{footnote F1}	-
Jul 12, 2026	Sean Brynjelsen - Officer	Option exercise	Restricted Stock Units	27,500	$0.00	-
Jul 14, 2026	Sean Brynjelsen - Officer	Option exercise	Employee Stock Option	200,000	$0.00	-
Footnote F1 (price): On July 12, 2022, the reporting person was granted 110,000 restricted stock units which vested in four equal installments beginning July 12, 2023.
Jul 12, 2026	David Krempa - Officer	Option exercise	Common Stock	10,000	-^{footnote F1}	-
Jul 12, 2026	David Krempa - Officer	Option exercise	Restricted Stock Units	10,000	$0.00	-
Footnote F1 (price): On July 12, 2022, the reporting person was granted 40,000 restricted stock units which vested in four equal annual installments beginning July 12, 2023.
Jul 6, 2026	Opaleye Management Inc. - 10% Owner	Open-market sale	Common Stock, par value $0.001 per share	10,000	$38.00	$380K
Jul 2, 2026	Opaleye Management Inc. - 10% Owner	Open-market sale	Common Stock, par value $0.001 per share	65,000	$37.39^{footnote F3}	$2.43M
Jul 2, 2026	Opaleye Management Inc. - 10% Owner	Open-market sale	Common Stock, par value $0.001 per share	25,000	$37.39^{footnote F3}	$935K
Jul 7, 2026	Opaleye Management Inc. - 10% Owner	Open-market sale	Common Stock, par value $0.001 per share	20,000	$38.37^{footnote F4}	$767K
Jul 7, 2026	Opaleye Management Inc. - 10% Owner	Open-market sale	Common Stock, par value $0.001 per share	6,685	$38.37^{footnote F4}	$257K
Footnote F3 (price): The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $37.05 to $37.85 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the… Full note on SEC EDGAR Footnote F4 (price): The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $38.00 to $38.565 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the… Full note on SEC EDGAR
Jun 26, 2026	David Krempa - Officer	Grant or award	Restricted Stock Units	10,000	$0.00	-
Jun 17, 2026	Jennifer McKie Adams - Director	Option exercise	Common Stock	50,000	$3.78	$189K
Jun 17, 2026	Jennifer McKie Adams - Director	Open-market sale	Common Stock	50,000	$32.48^{footnote F1,F3}	$1.62M
Jun 17, 2026	Jennifer McKie Adams - Director	Option exercise	Employee Stock Option	50,000	$0.00	-
Footnote F1 (price): The Reporting Person will provide upon request by the Securities and Exchange Commission staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price. Footnote F3 (price): The shares were sold in multiple trades at prices ranging from $32.10 to $32.71. The price reported above reflects the weighted average sales price.
May 28, 2026	Sean Brynjelsen - Officer	Open-market sale	Common Stock	148	$32.67	$5K
May 28, 2026	Sean Brynjelsen - Officer	Open-market sale	Common Stock	119,852	$31.88^{footnote F1,F2}	$3.82M
Footnote F1 (price): The shares were sold in multiple trades at prices ranging from $31.59 to $32.55. The price above reflects the weighted average sales price. Footnote F2 (price): The Reporting Person will provide upon request by the Securities and Exchange Commission staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price.
May 22, 2026	David Krempa - Officer	Option exercise	Common Stock	30,591	$3.58	$110K
May 22, 2026	David Krempa - Officer	Open-market sale	Common Stock	519	$35.00	$18K
May 26, 2026	David Krempa - Officer	Option exercise	Common Stock	25,000	$1.38	$35K
May 26, 2026	David Krempa - Officer	Option exercise	Common Stock	12,524	$1.37	$17K
May 27, 2026	David Krempa - Officer	Option exercise	Common Stock	12,476	$1.37	$17K
May 27, 2026	David Krempa - Officer	Option exercise	Common Stock	7,203	$3.58	$26K
May 22, 2026	David Krempa - Officer	Open-market sale	Common Stock	32,963	$33.22^{footnote F1,F7}	$1.10M
May 22, 2026	David Krempa - Officer	Open-market sale	Common Stock	9,315	$33.88^{footnote F1,F2}	$316K
May 26, 2026	David Krempa - Officer	Open-market sale	Common Stock	37,524	$31.49^{footnote F1,F3}	$1.18M
May 27, 2026	David Krempa - Officer	Open-market sale	Common Stock	19,679	$31.47^{footnote F1,F5}	$619K
May 22, 2026	David Krempa - Officer	Option exercise	Employee Stock Option	30,591	$0.00	-
May 26, 2026	David Krempa - Officer	Option exercise	Employee Stock Option	25,000	$0.00	-
May 26, 2026	David Krempa - Officer	Option exercise	Employee Stock Option	12,524	$0.00	-
May 27, 2026	David Krempa - Officer	Option exercise	Employee Stock Option	12,476	$0.00	-
May 27, 2026	David Krempa - Officer	Option exercise	Employee Stock Option	7,203	$0.00	-
Footnote F1 (price): The Reporting Person will provide upon request by the Securities and Exchange Commission staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price. Footnote F2 (price): The shares were sold in multiple trades at prices ranging from $33.68 to $34.66. The price reported above reflects the weighted average sales price. Footnote F3 (price): The shares were sold in multiple trades at prices ranging from $31.27 to $32.16. The price reported above reflects the weighted average sales price. Footnote F5 (price): The shares were sold in multiple trades at prices ranging from $31.25 to $31.825. The price reported above reflects the weighted average sales price. Footnote F7 (price): The shares were sold in multiple trades at prices ranging from $32.67 to $33.65. The price reported above reflects the weighted average sales price.
Apr 21, 2026	Norbert G. Riedel - Director	Option exercise	Common Stock	12,500	$7.31	$91K
Apr 21, 2026	Norbert G. Riedel - Director	Option exercise	Common Stock	19,655	$8.61	$169K
Apr 21, 2026	Norbert G. Riedel - Director	Option exercise	Employee Stock Option (Right to Buy)	12,500	$0.00	-
Apr 21, 2026	Norbert G. Riedel - Director	Option exercise	Employee Stock Option (Right to Buy)	19,655	$0.00	-
Feb 3, 2026	Norbert G. Riedel - Director	Other	Common Stock	30,000	$4.42	$133K
Feb 3, 2026	Norbert G. Riedel - Director	Other	Employee Stock Option (Right to Buy)	30,000	$0.00	-
Jan 12, 2026	Norbert G. Riedel - Director	Grant or award	Employee Stock Option (Right to Buy)	12,196	$0.00	-
Jan 12, 2026	Norbert G. Riedel - Director	Grant or award	Restricted Stock Units	7,757	$0.00	-
Jan 12, 2026	Jennifer McKie Adams - Director	Grant or award	Employee Stock Option (Right to Buy)	12,196	$0.00	-
Jan 12, 2026	Jennifer McKie Adams - Director	Grant or award	Restricted Stock Units	7,757	$0.00	-
Jan 12, 2026	Charles J. Casamento - Director	Grant or award	Employee Stock Option (Right to Buy)	12,196	$0.00	-
Jan 12, 2026	Charles J. Casamento - Director	Grant or award	Restricted Stock Units	7,757	$0.00	-
Jan 12, 2026	Paul V. Maier - Director	Grant or award	Employee Stock Option (Right to Buy)	12,196	$0.00	-
Jan 12, 2026	Paul V. Maier - Director	Grant or award	Restricted Stock Units	7,757	$0.00	-
Jan 12, 2026	Ipek Erdogan-Trinkaus - Officer	Grant or award	Employee Stock Option (Right to Buy)	40,655	$0.00	-
Jan 12, 2026	Ipek Erdogan-Trinkaus - Officer	Grant or award	Restricted Stock Units	25,856	$0.00	-
Jan 1, 2026	Sean Brynjelsen - Officer	Tax withholding / forfeiture	Common Stock	5,015^{footnote F1}	$15.39^{footnote F2,F3}	$77K
Jan 12, 2026	Sean Brynjelsen - Officer	Grant or award	Employee Stock Option (Right to Buy)	158,046	$0.00	-
Jan 12, 2026	Sean Brynjelsen - Officer	Grant or award	Restricted Stock Units	100,517	$0.00	-
Footnote F1 (shares): Shares withheld by the Issuer to satisfy applicable withholding taxes upon the vesting of restricted stock units. Footnote F2 (price): The shares were sold in multiple trades at prices ranging from $15.39 to $15.42. The price reported above reflects the weighted average sales price. Footnote F3 (price): The Reporting Person will provide upon request by the Securities and Exchange Commission staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased or sold at each separate price.

Recent ETON Form 8-K filings

Read ETON company news

Oct 14, 2026Item 1.01, 2.01, 9.01

Read the filing on SEC EDGAR

Sep 28, 2026Item 8.01, 9.01

Read the filing on SEC EDGAR

Aug 13, 2026Item 2.02, 9.01

Read the filing on SEC EDGAR

Aug 5, 2026Item 1.01, 2.01, 9.01

Recent ETON Form 144 notices of proposed sale

An insider files Form 144 before selling restricted or control stock. It announces a planned sale. If the sale goes ahead, it shows up later on a Form 4.

Filed	Filer	Relationship	Shares	Market value	Notice
Oct 6, 2026	Krempa David	Officer	4,166	$229K	View on EDGAR
Aug 28, 2026	MAIER PAUL V	Director	50,000

ETON insider trading FAQ

What is the latest insider trade for ETON?

Eton Pharmaceuticals, Inc. (ETON) had 15 insider filings in the last 90 days, with the most recent on 2026-10-06. The full record for ETON runs to 36 Form 4 filings, the earliest from 2024-10-04. InsiderAlpha adds new Form 4, Form 144 and 8-K filings as they arrive from SEC EDGAR.

How many insiders are buying ETON stock?

No insider purchases of ETON were filed in the last 90 days. 7 purchases are on record for this company.

How many insiders are selling ETON stock?

16 insider sales of ETON were filed in the last 90 days, totaling $15.98M.

Where can I see ETON SEC filings (Form 4, 10-K, 10-Q, 8-K)?

This page collects ETON Form 4 insider transactions, Form 144 sale notices and 8-K filings in one place. Annual 10-K and quarterly 10-Q reports live on the company's SEC EDGAR page.

More Health Care companies with insider activity

Recent insider filings

The EDGAR links open each original Form 4, so you can check any number on this page against the filing it came from.

Oct 6, 2026 - David Krempa view on EDGAR
Aug 31, 2026 - Paul V. Maier view on EDGAR
Aug 28, 2026 - Paul V. Maier view on EDGAR
Aug 24, 2026 - David Krempa view on EDGAR
Aug 20, 2026 - Sean Brynjelsen view on EDGAR
Aug 4, 2026 - Charles J. Casamento view on EDGAR
Aug 4, 2026 - Judith M. Matthews view on EDGAR
Aug 4, 2026 - Ipek Erdogan-Trinkaus view on EDGAR
Aug 4, 2026 - Sean Brynjelsen view on EDGAR

Related companies with recent insider activity

Learn more

Insider selling: signal or noise?: Why most insider sales are routine, and the few patterns worth a second look.
Form 144 vs Form 4: A Form 144 announces a planned sale; the Form 4 reports it after it happens.
Insider activity in Health Care: Where ETON's peers are being bought and sold.
Every recent Form 4: The market-wide feed, updated as filings arrive from SEC EDGAR.

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Form 4 transaction type

Transactions

Total value

Open-market sale

285,796

$15.98M

Grant or award

410,216

Option exercise

296,044

Date

Insider

Transaction

Security

Price

Value

Oct 2, 2026

David Krempa - Officer

Option exercise

Common Stock

10,522

-^{footnote F3}

Oct 6, 2026

David Krempa - Officer

Open-market sale

Common Stock

4,166

$55.07^{footnote F1,F2}

$229K

Oct 2, 2026

David Krempa - Officer

Option exercise

Restricted Stock Units

10,522

$0.00

Footnote F1 (price): The Reporting Person will provide upon request by the Securities and Exchange Commission staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased or sold at each separate price.
Footnote F2 (price): The shares were sold in multiple trades at prices ranging from $54.915 to $55.135. The price reported above reflects the weighted average sales price.
Footnote F3 (price): On October 2, 2024, the reporting person was granted 42,088 restricted stock units which vest in four equal annual installments beginning October 2, 2025.

Aug 28, 2026

Paul V. Maier - Director

Option exercise

Common Stock

50,000

$3.78

$189K

Aug 28, 2026

Paul V. Maier - Director

Open-market sale

Common Stock

36,387

$58.64^{footnote F1,F2}

$2.13M

Aug 28, 2026

Paul V. Maier - Director

Open-market sale

Common Stock

13,485

$60.21^{footnote F1,F4}

$812K

Aug 28, 2026

Paul V. Maier - Director

Open-market sale

Common Stock

128

$61.77^{footnote F1,F5}

$8K

Aug 28, 2026

Paul V. Maier - Director

Option exercise

Common Stock

12,500

$7.31

$91K

Aug 28, 2026

Paul V. Maier - Director

Option exercise

Employee Stock Option

50,000

$0.00

Aug 28, 2026

Paul V. Maier - Director

Option exercise

Employee Stock Option

12,500

$0.00

Footnote F1 (price): The Reporting Person will provide upon request by the Securities and Exchange Commission staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased or sold at each separate price.
Footnote F2 (price): The shares were sold in multiple trades at prices ranging from $58.50 to $58.97. The price reported above reflects the weighted average sales price.
Footnote F4 (price): The shares were sold in multiple trades at prices ranging from $60.00 to $61.00. The price reported above reflects the weighted average sales price.
Footnote F5 (price): The shares were sold in multiple trades at prices ranging from $61.10 to $61.98. The price reported above reflects the weighted average sales price.

Aug 28, 2026

Paul V. Maier - Director

Option exercise

Common Stock

50,000

$3.78

$189K

Aug 28, 2026

Paul V. Maier - Director

Open-market sale

Common Stock

36,387

$58.64^{footnote F1,F2}

$2.13M

Aug 28, 2026

Paul V. Maier - Director

Open-market sale

Common Stock

13,485

$60.21^{footnote F1,F4}

$812K

Aug 28, 2026

Paul V. Maier - Director

Open-market sale

Common Stock

128

$61.77^{footnote F1,F5}

$8K

Aug 28, 2026

Paul V. Maier - Director

Option exercise

Employee Stock Option

50,000

$0.00

Footnote F1 (price): The Reporting Person will provide upon request by the Securities and Exchange Commission staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased or sold at each separate price.
Footnote F2 (price): The shares were sold in multiple trades at prices ranging from $58.50 to $58.97. The price reported above reflects the weighted average sales price.
Footnote F4 (price): The shares were sold in multiple trades at prices ranging from $60.00 to $61.00. The price reported above reflects the weighted average sales price.
Footnote F5 (price): The shares were sold in multiple trades at prices ranging from $61.10 to $61.98. The price reported above reflects the weighted average sales price.

Aug 24, 2026

David Krempa - Officer

Option exercise

Common Stock

25,000

$7.31

$183K

Aug 24, 2026

David Krempa - Officer

Open-market sale

Common Stock

25,000

$65.07^{footnote F1,F2}

$1.63M

Aug 24, 2026

David Krempa - Officer

Option exercise

Employee Stock Option

25,000

$0.00

Footnote F1 (price): The Reporting Person will provide upon request by the Securities and Exchange Commission staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased or sold at each separate price.
Footnote F2 (price): The shares were sold in multiple trades at prices ranging from $64.88 to $65.57. The price reported above reflects the weighted average sales price.

Aug 19, 2026

Sean Brynjelsen - Officer

Open-market sale

Common Stock

8,978

$62.65^{footnote F1,F2}

$562K

Aug 20, 2026

Sean Brynjelsen - Officer

Open-market sale

Common Stock

47,307

$60.17^{footnote F2,F3}

$2.85M

Aug 20, 2026

Sean Brynjelsen - Officer

Open-market sale

Common Stock

36,373

$61.11^{footnote F2,F4}

$2.22M

Aug 20, 2026

Sean Brynjelsen - Officer

Open-market sale

Common Stock

7,342

$62.12^{footnote F2,F5}

$456K

Footnote F1 (price): The shares were sold in multiple trades at prices ranging from $62.50 to $63.41. The price above reflects the weighted average sales price.
Footnote F2 (price): The Reporting Person will provide upon request by the Securities and Exchange Commission staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price.
Footnote F3 (price): The shares were sold in multiple trades at prices ranging from $59.59 to $60.59. The price above reflects the weighted average sales price.
Footnote F4 (price): The shares were sold in multiple trades at prices ranging from $60.61 to $61.61. The price above reflects the weighted average sales price.
Footnote F5 (price): The shares were sold in multiple trades at prices ranging from $61.63 to $62.52. The price above reflects the weighted average sales price.

Jul 31, 2026

Charles J. Casamento - Director

Grant or award

Common Stock

10,000

$0.00

Jul 31, 2026

Judith M. Matthews - Officer

Grant or award

Common Stock

32,246

$0.00

Jul 31, 2026

Ipek Erdogan-Trinkaus - Officer

Grant or award

Common Stock

80,000

$0.00

Jul 31, 2026

Sean Brynjelsen - Officer

Grant or award

Common Stock

128,985

$0.00

Jul 31, 2026

David Krempa - Officer

Grant or award

Common Stock

128,985

$0.00

Jul 31, 2026

Paul V. Maier - Director

Grant or award

Common Stock

10,000

$0.00

Jul 31, 2026

Norbert G. Riedel - Director

Grant or award

Common Stock

10,000

$0.00

Jul 31, 2026

Jennifer McKie Adams - Director

Grant or award

Common Stock

10,000

$0.00

Jul 14, 2026

Opaleye Management Inc. - 10% Owner

Open-market sale

Common Stock, par value $0.001 per share

15,000

$37.54

$563K

Jul 14, 2026

Opaleye Management Inc. - 10% Owner

Open-market sale

Common Stock, par value $0.001 per share

13,315

$37.54

$500K

Jul 14, 2026

Opaleye Management Inc. - 10% Owner

Open-market sale

Common Stock, par value $0.001 per share

15,000

$37.54^{footnote F3}

$563K

Jul 14, 2026

Opaleye Management Inc. - 10% Owner

Open-market sale

Common Stock, par value $0.001 per share

13,315

$37.54^{footnote F3}

$500K

Footnote F3 (price): The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $37.0152 to $37.9148 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the… Full note on SEC EDGAR

Jul 14, 2026

Sean Brynjelsen - Officer

Option exercise

Common Stock

200,000

$1.37

$274K

Jul 12, 2026

Sean Brynjelsen - Officer

Option exercise

Common Stock

27,500

-^{footnote F1}

Jul 12, 2026

Sean Brynjelsen - Officer

Option exercise

Restricted Stock Units

27,500

$0.00

Jul 14, 2026

Sean Brynjelsen - Officer

Option exercise

Employee Stock Option

200,000

$0.00

Footnote F1 (price): On July 12, 2022, the reporting person was granted 110,000 restricted stock units which vested in four equal installments beginning July 12, 2023.

Jul 12, 2026

David Krempa - Officer

Option exercise

Common Stock

10,000

-^{footnote F1}

Jul 12, 2026

David Krempa - Officer

Option exercise

Restricted Stock Units

10,000

$0.00

Footnote F1 (price): On July 12, 2022, the reporting person was granted 40,000 restricted stock units which vested in four equal annual installments beginning July 12, 2023.

Jul 6, 2026

Opaleye Management Inc. - 10% Owner

Open-market sale

Common Stock, par value $0.001 per share

10,000

$38.00

$380K

Jul 2, 2026

Opaleye Management Inc. - 10% Owner

Open-market sale

Common Stock, par value $0.001 per share

65,000

$37.39^{footnote F3}

$2.43M

Jul 2, 2026

Opaleye Management Inc. - 10% Owner

Open-market sale

Common Stock, par value $0.001 per share

25,000

$37.39^{footnote F3}

$935K

Jul 7, 2026

Opaleye Management Inc. - 10% Owner

Open-market sale

Common Stock, par value $0.001 per share

20,000

$38.37^{footnote F4}

$767K

Jul 7, 2026

Opaleye Management Inc. - 10% Owner

Open-market sale

Common Stock, par value $0.001 per share

6,685

$38.37^{footnote F4}

$257K

Footnote F3 (price): The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $37.05 to $37.85 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the… Full note on SEC EDGAR
Footnote F4 (price): The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $38.00 to $38.565 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the… Full note on SEC EDGAR

Jun 26, 2026

David Krempa - Officer

Grant or award

Restricted Stock Units

10,000

$0.00

Jun 17, 2026

Jennifer McKie Adams - Director

Option exercise

Common Stock

50,000

$3.78

$189K

Jun 17, 2026

Jennifer McKie Adams - Director

Open-market sale

Common Stock

50,000

$32.48^{footnote F1,F3}

$1.62M

Jun 17, 2026

Jennifer McKie Adams - Director

Option exercise

Employee Stock Option

50,000

$0.00

Footnote F1 (price): The Reporting Person will provide upon request by the Securities and Exchange Commission staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price.
Footnote F3 (price): The shares were sold in multiple trades at prices ranging from $32.10 to $32.71. The price reported above reflects the weighted average sales price.

May 28, 2026

Sean Brynjelsen - Officer

Open-market sale

Common Stock

148

$32.67

$5K

May 28, 2026

Sean Brynjelsen - Officer

Open-market sale

Common Stock

119,852

$31.88^{footnote F1,F2}

$3.82M

Footnote F1 (price): The shares were sold in multiple trades at prices ranging from $31.59 to $32.55. The price above reflects the weighted average sales price.
Footnote F2 (price): The Reporting Person will provide upon request by the Securities and Exchange Commission staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price.

May 22, 2026

David Krempa - Officer

Option exercise

Common Stock

30,591

$3.58

$110K

May 22, 2026

David Krempa - Officer

Open-market sale

Common Stock

519

$35.00

$18K

May 26, 2026

David Krempa - Officer

Option exercise

Common Stock

25,000

$1.38

$35K

May 26, 2026

David Krempa - Officer

Option exercise

Common Stock

12,524

$1.37

$17K

May 27, 2026

David Krempa - Officer

Option exercise

Common Stock

12,476

$1.37

$17K

May 27, 2026

David Krempa - Officer

Option exercise

Common Stock

7,203

$3.58

$26K

May 22, 2026

David Krempa - Officer

Open-market sale

Common Stock

32,963

$33.22^{footnote F1,F7}

$1.10M

May 22, 2026

David Krempa - Officer

Open-market sale

Common Stock

9,315

$33.88^{footnote F1,F2}

$316K

May 26, 2026

David Krempa - Officer

Open-market sale

Common Stock

37,524

$31.49^{footnote F1,F3}

$1.18M

May 27, 2026

David Krempa - Officer

Open-market sale

Common Stock

19,679

$31.47^{footnote F1,F5}

$619K

May 22, 2026

David Krempa - Officer

Option exercise

Employee Stock Option

30,591

$0.00

May 26, 2026

David Krempa - Officer

Option exercise

Employee Stock Option

25,000

$0.00

May 26, 2026

David Krempa - Officer

Option exercise

Employee Stock Option

12,524

$0.00

May 27, 2026

David Krempa - Officer

Option exercise

Employee Stock Option

12,476

$0.00

May 27, 2026

David Krempa - Officer

Option exercise

Employee Stock Option

7,203

$0.00

Footnote F1 (price): The Reporting Person will provide upon request by the Securities and Exchange Commission staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price.
Footnote F2 (price): The shares were sold in multiple trades at prices ranging from $33.68 to $34.66. The price reported above reflects the weighted average sales price.
Footnote F3 (price): The shares were sold in multiple trades at prices ranging from $31.27 to $32.16. The price reported above reflects the weighted average sales price.
Footnote F5 (price): The shares were sold in multiple trades at prices ranging from $31.25 to $31.825. The price reported above reflects the weighted average sales price.
Footnote F7 (price): The shares were sold in multiple trades at prices ranging from $32.67 to $33.65. The price reported above reflects the weighted average sales price.

Apr 21, 2026

Norbert G. Riedel - Director

Option exercise

Common Stock

12,500

$7.31

$91K

Apr 21, 2026

Norbert G. Riedel - Director

Option exercise

Common Stock

19,655

$8.61

$169K

Apr 21, 2026

Norbert G. Riedel - Director

Option exercise

Employee Stock Option (Right to Buy)

12,500

$0.00

Apr 21, 2026

Norbert G. Riedel - Director

Option exercise

Employee Stock Option (Right to Buy)

19,655

$0.00

Feb 3, 2026

Norbert G. Riedel - Director

Other

Common Stock

30,000

$4.42

$133K

Feb 3, 2026

Norbert G. Riedel - Director

Other

Employee Stock Option (Right to Buy)

30,000

$0.00

Jan 12, 2026

Norbert G. Riedel - Director

Grant or award

Employee Stock Option (Right to Buy)

12,196

$0.00

Jan 12, 2026

Norbert G. Riedel - Director

Grant or award

Restricted Stock Units

7,757

$0.00

Jan 12, 2026

Jennifer McKie Adams - Director

Grant or award

Employee Stock Option (Right to Buy)

12,196

$0.00

Jan 12, 2026

Jennifer McKie Adams - Director

Grant or award

Restricted Stock Units

7,757

$0.00

Jan 12, 2026

Charles J. Casamento - Director

Grant or award

Employee Stock Option (Right to Buy)

12,196

$0.00

Jan 12, 2026

Charles J. Casamento - Director

Grant or award

Restricted Stock Units

7,757

$0.00

Jan 12, 2026

Paul V. Maier - Director

Grant or award

Employee Stock Option (Right to Buy)

12,196

$0.00

Jan 12, 2026

Paul V. Maier - Director

Grant or award

Restricted Stock Units

7,757

$0.00

Jan 12, 2026

Ipek Erdogan-Trinkaus - Officer

Grant or award

Employee Stock Option (Right to Buy)

40,655

$0.00

Jan 12, 2026

Ipek Erdogan-Trinkaus - Officer

Grant or award

Restricted Stock Units

25,856

$0.00

Jan 1, 2026

Sean Brynjelsen - Officer

Tax withholding / forfeiture

Common Stock

5,015^{footnote F1}

$15.39^{footnote F2,F3}

$77K

Jan 12, 2026

Sean Brynjelsen - Officer

Grant or award

Employee Stock Option (Right to Buy)

158,046

$0.00

Jan 12, 2026

Sean Brynjelsen - Officer

Grant or award

Restricted Stock Units

100,517

$0.00

Footnote F1 (shares): Shares withheld by the Issuer to satisfy applicable withholding taxes upon the vesting of restricted stock units.
Footnote F2 (price): The shares were sold in multiple trades at prices ranging from $15.39 to $15.42. The price reported above reflects the weighted average sales price.
Footnote F3 (price): The Reporting Person will provide upon request by the Securities and Exchange Commission staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased or sold at each separate price.

Filed

Filer

Relationship

Market value

Notice

Oct 6, 2026

Krempa David

Officer

4,166

$229K

View on EDGAR

Aug 28, 2026

MAIER PAUL V

Director

50,000