Summary
Updated Aug 31, 2026
Andrew Combs is Chief Chemistry Officer of Prelude Therapeutics Inc (PRLD). 2 SEC Form 4 filings on record going back to 2024, most recently on 5 February 2026. Most recent open-market trade: bought $82K of PRLD on 26 December 2024. Lifetime open-market purchases: $86K.
Recent Transactions
2Every recent SEC Form 4 transaction Andrew Combs has reported, most recent first.
Trading Pattern
InsiderAlpha's records for Andrew Combs go back to 2024: 2 primary Form 4 filings, an average of 0.7 per year. The typical open-market purchase is $43K (2 buys totaling $86K). The largest single buy on record is $82K of PRLD in 2024. No transaction on record carries a Rule 10b5-1 flag - the filings look discretionary rather than pre-scheduled, which makes their timing more informative as a signal.
Other Insiders Active in the Same Stocks
Insiders who reported open-market trades in the last 12 months at the companies Andrew Combs files at. Multiple unrelated insiders buying the same stock within a short window, cluster buying, has historically been one of the strongest Form 4 signals.
- ORBIMED ADVISORS LLC - $12.50M of PRLD open-market activity in the last 12 months
- David P. Bonita - $12.50M of PRLD open-market activity in the last 12 months
- BAKER BROS. ADVISORS LP - $10.00M of PRLD open-market activity in the last 12 months
More Notable Insiders
Other corporate insiders with significant SEC Form 4 track records on InsiderAlpha:
Frequently Asked Questions
Who is Andrew Combs?
Andrew Combs is a corporate insider, tracked as Chief Chemistry Officer of Prelude Therapeutics Inc (PRLD). InsiderAlpha holds 2 primary Form 4 filings for them, the earliest from 2024, updated as new SEC EDGAR filings are processed.
When did Andrew Combs last file a Form 4?
The most recent primary Form 4 on record is dated 5 February 2026, one of 2 filings going back to 2024.
Has Andrew Combs been buying or selling stock?
Recorded transactions: 2 open-market purchases ($86K) and 0 open-market sales across all tracked filings.
Where can I see all of Andrew Combs's SEC filings?
All Form 4 filings, transaction values, and 10b5-1 plan flags are listed on this page and updated in real time as new SEC EDGAR filings are processed.
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