Upstream Bio, Inc. (UPB)
Data as of , from SEC Form 4 filings.
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Michael Gray - OfficerOpen-market sale$5K- Allison Ambrose - Officer
About Upstream Bio, Inc. (UPB)
Upstream Bio Inc is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. It is developing verekitug, the known antagonist currently in clinical development that targets the receptor for Thymic Stromal Lymphopoietin (TSLP), a cytokine that is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune-mediated diseases. Verekitug has advanced into three separate world-wide, placebo-controlled, randomized Phase 2 clinical trials, two completed in chronic rhinosinusitis with nasal polyps (CRSwNP) and severe asthma, and one ongoing in chronic obstructive pulmonary disease (COPD).
- WALTHAM, MA
- 75
- 2024
- XNAS
UPB Form 4 activity by transaction type, last 90 days
| Form 4 transaction type | Transactions | Shares | Total value |
|---|---|---|---|
| Open-market sale | 5 | 5,028 | $28K |
UPB insider transactions (Form 4)
837 Form 4 filings on record, the earliest from Oct 15, 2024, newest first. Filing history page 2 of 2.
| Date | Insider | Transaction | Security | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Marcella K. Ruddy | Grant or award | Stock Option (Right to Buy) | 17,096 | $0.00 | - | |
| Wellington Biomedical Innovation Master Investors (Cayman) II L.P. | Other | Common Stock | 894,733 | - | - | |
| Wellington Biomedical Innovation Master Investors (Cayman) II L.P. | Other | Series B redeemable convertible preferred stock | 852,940 | $0.00 | - | |
| Harold Edward Fleming | Grant or award | Stock Option (Right to Buy) | 17,096 | $0.00 | - | |
| Erez Chimovits | Grant or award | Stock Option (Right to Buy) | 17,096 | $0.00 | - | |
| Liam Ratcliffe | Grant or award | Stock Option (Right to Buy) | 17,096 | $0.00 | - | |
 Daniella Beckman | Grant or award | Stock Option (Right to Buy) | 34,681 | $0.00 | - | |
| Ronald C. Renaud Jr. | Grant or award | Stock Option (Right to Buy) | 17,096 | $0.00 | - |
UPB insider trading FAQ
What is the latest insider trade for UPB?
Upstream Bio, Inc. (UPB) had 5 insider filings in the last 90 days, with the most recent on 2026-09-17. The full record for UPB runs to 37 Form 4 filings, the earliest from 2024-10-15. InsiderAlpha adds new Form 4, Form 144 and 8-K filings as they arrive from SEC EDGAR.
How many insiders are buying UPB stock?
No insider purchases of UPB were filed in the last 90 days. 5 purchases are on record for this company.
How many insiders are selling UPB stock?
5 insider sales of UPB were filed in the last 90 days, totaling $28K.
Where can I see UPB SEC filings (Form 4, 10-K, 10-Q, 8-K)?
This page collects UPB Form 4 insider transactions, Form 144 sale notices and 8-K filings in one place. Annual 10-K and quarterly 10-Q reports live on the company's SEC EDGAR page.
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Recent insider filings
10The EDGAR links open each original Form 4, so you can check any number on this page against the filing it came from.
- - Michael Gray view on EDGAR
- - Allison Ambrose view on EDGAR
- - Aaron Deykin view on EDGAR
- - Everett Rand Sutherland view on EDGAR
- - Adam Houghton view on EDGAR
- - Michael Gray view on EDGAR
- - Everett Rand Sutherland view on EDGAR
- - Adam Houghton view on EDGAR
- - Aaron Deykin view on EDGAR
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Learn more
- Insider selling: signal or noise?
- Why most insider sales are routine, and the few patterns worth a second look.
- Insider activity in Health Care
- Where UPB's peers are being bought and sold.
- Every recent Form 4
- The market-wide feed, updated as filings arrive from SEC EDGAR.
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