Upstream Bio, Inc. (UPB) Insider Trading & SEC Filings

Updated Jul 16, 2026 · Last SEC filing 2026-06-17

Upstream Bio, Inc. (UPB) has filed 11 SEC Form 4 insider transactions in the last 90 days, with the most recent on 2026-06-17. 2 Form 8-K material event filings were reported by UPB in the last 90 days. InsiderAlpha tracks every UPB SEC filing — Form 4, Form 144, and 8-K — in real time, including Rule 10b5-1 plan detection.

About Upstream Bio, Inc. (UPB)

SEC CIK	0002022626

90-Day SEC Filing Activity

Form 4 filings (90d)	11
Form 8-K filings (90d)	2
Latest Form 4 filing	2026-06-17

Recent UPB Insider Transactions (Form 4)

Date	Insider	Role	Transaction	Shares	Price	Value	Filing
2026-06-16	GRAY MICHAEL	CFO and COO	S — Open-market sale	853	$6.10	$5K	SEC
2026-06-16	Ambrose Allison	General Counsel	S — Open-market sale	477	$6.10	$3K	SEC
2026-06-16	Deykin Aaron	Chief Medical Officer	S — Open-market sale	895	$6.10	$5K	SEC
2026-06-16	Houghton Adam	Chief Business Officer	S — Open-market sale	700	$6.10	$4K	SEC
2026-06-16	Sutherland Everett Rand	Chief Executive Officer	S — Open-market sale	2.1K	$6.10	$13K	SEC
2026-03-16	Deykin Aaron	Chief Medical Officer	S — Open-market sale	894	$9.29	$8K	SEC
2026-03-16	Houghton Adam	Chief Business Officer	S — Open-market sale	699	$9.29	$6K	SEC
2026-03-16	Ambrose Allison	General Counsel	S — Open-market sale	475	$9.29	$4K	SEC
2026-03-16	Sutherland Everett Rand	Chief Executive Officer	S — Open-market sale	2.1K	$9.29	$19K	SEC
2026-03-16	GRAY MICHAEL	CFO and COO	S — Open-market sale	852	$9.29	$8K	SEC
2026-01-02	Deykin Aaron	Chief Medical Officer	A — Grant or award	32.0K	$0.00	—	SEC
2026-01-02	GRAY MICHAEL	CFO and COO	A — Grant or award	30.5K	$0.00	—	SEC
2026-01-02	Ambrose Allison	General Counsel	A — Grant or award	17.0K	$0.00	—	SEC
2026-01-02	Sutherland Everett Rand	Chief Executive Officer	A — Grant or award	75.0K	$0.00	—	SEC
2026-01-02	Houghton Adam	Chief Business Officer	A — Grant or award	25.0K	$0.00	—	SEC

All transactions sourced from SEC EDGAR Form 4 filings for Upstream Bio, Inc. (UPB). Updated in real time as new filings are submitted to the SEC.

Most-Active UPB Insiders — Last 90 Days

Insider	Form 4 filings	Total transaction value
Ruddy Marcella K.	1	—
Renaud Ronald C JR	1	—
Ratcliffe Liam	1	—
Chimovits Erez	1	—
Beckman Daniella	1	—

Recent UPB Form 8-K Material Events

2026-06-10 — Item 5.07 [SEC]
2026-05-13 — Item 2.02, 9.01 [SEC]
2026-03-26 — Item 1.01, 9.01 · Financing · neutral [SEC]
Upstream Bio entered into an at-the-market (ATM) sales agreement with Leerink Partners LLC to offer and sell up to $150 million in common stock shares. The company may offer and sell shares from time to time at prevailing market prices, with the sales agent receiving a 3.0% commi
2026-03-26 — Item 2.02, 9.01 · Earnings · neutral [SEC]
Upstream Bio announced its financial results and business highlights for Q4 2025 and full year 2025 on March 26, 2026. The filing provides standard quarterly and annual financial results without explicit beat/miss or guidance language.

Recent Insider Filings

2026-06-17 — GRAY MICHAEL (CFO and COO)
2026-06-17 — Sutherland Everett Rand (Chief Executive Officer)
2026-06-17 — Houghton Adam (Chief Business Officer)
2026-06-17 — Deykin Aaron (Chief Medical Officer)
2026-06-17 — Ambrose Allison (General Counsel)

Form 4 Transaction Code Reference

SEC Form 4 transactions are reported with a one-letter code indicating the type of transaction. Common codes you'll see in UPB insider filings:

P	Open-market purchase by the insider
S	Open-market sale by the insider
A	Grant, award, or other acquisition from the issuer
M	Exercise or conversion of derivative security (e.g. options)
F	Payment of exercise price or tax liability via share withholding
G	Bona-fide gift of securities
D	Disposition to the issuer (e.g. share buyback participation)
J	Other acquisition or disposition
X	Exercise of in-the-money or at-the-money derivative security
C	Conversion of derivative security
V	Transaction voluntarily reported earlier than required

UPB Insider Trading — FAQ

What is the latest insider trade for UPB?: Upstream Bio, Inc. (UPB) had 11 insider filings in the last 90 days, with the most recent on 2026-06-17. InsiderAlpha tracks every Form 4, 10-K, 10-Q, and 8-K filing in real time.
How many insiders are buying UPB stock?: 0 insider purchases of UPB were filed in the last 90 days.
How many insiders are selling UPB stock?: 0 insider sales of UPB were filed in the last 90 days.
Where can I see UPB SEC filings (Form 4, 10-K, 10-Q, 8-K)?: InsiderAlpha aggregates every UPB SEC filing — Form 4 insider transactions, 10-K and 10-Q quarterly reports, and 8-K material event disclosures — in one timeline.

Learn More

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