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Michael Gray - OfficerOpen-market sale$5K- Allison Ambrose - Officer
About Upstream Bio, Inc. (UPB)
Upstream Bio, Inc. files with the SEC under CIK 0002022626 and is classified as pharmaceutical preparations. We track it alongside the rest of the Health Care sector.
UPB Form 4 activity by transaction type, last 90 days
| Form 4 transaction type | Transactions | Shares | Total value |
|---|---|---|---|
| Open-market sale | 5 | 5,028 | $28K |
UPB insider transactions (Form 4)
5337 Form 4 filings on record, the earliest from Oct 15, 2024, newest first. Filing history page 1 of 2.
| Date | Insider | Transaction | Security | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Michael Gray - Officer | Open-market sale | Common Stock | 853 | $5.49 | $5K | |
| Allison Ambrose - Officer | Open-market sale | Common Stock | 485 | $5.49 | $3K | |
 Aaron Deykin - Officer | Open-market sale | Common Stock | 895 | $5.49 | $5K | |
 Everett Rand Sutherland - Officer | Open-market sale | Common Stock | 2,095 | $5.49 | $12K | |
| Adam Houghton - Officer | Open-market sale | Common Stock | 700 | $5.49 | $4K | |
| Michael Gray - Officer | Open-market sale | Common Stock | 853 | $6.10 | $5K | |
| Everett Rand Sutherland - Officer | Open-market sale | Common Stock | 2,095 | $6.10 | $13K | |
| Adam Houghton - Officer | Open-market sale | Common Stock | 700 | $6.10 | $4K | |
| Aaron Deykin - Officer | Open-market sale | Common Stock | 895 | $6.10 | $5K | |
| Allison Ambrose - Officer | Open-market sale | Common Stock | 477 | $6.10 | $3K | |
| Marcella K. Ruddy | Grant or award | Stock Option (Right to Buy) | 17,096 | $0.00 | - | |
| Ronald C. Renaud Jr. | Grant or award | Stock Option (Right to Buy) | 17,096 | $0.00 | - | |
| Harold Edward Fleming | Grant or award | Stock Option (Right to Buy) | 17,096 | $0.00 | - | |
 Daniella Beckman | Grant or award | Stock Option (Right to Buy) | 17,096 | $0.00 | - | |
| Liam Ratcliffe | Grant or award | Stock Option (Right to Buy) | 17,096 | $0.00 | - | |
| Erez Chimovits | Grant or award | Stock Option (Right to Buy) | 17,096 | $0.00 | - | |
| Michael Gray - Officer | Open-market sale | Common Stock | 852 | $9.29 | $8K | |
| Aaron Deykin - Officer | Open-market sale | Common Stock | 894 | $9.29 | $8K | |
| Everett Rand Sutherland - Officer | Open-market sale | Common Stock | 2,093 | $9.29 | $19K | |
| Allison Ambrose - Officer | Open-market sale | Common Stock | 475 | $9.29 | $4K | |
| Adam Houghton - Officer | Open-market sale | Common Stock | 699 | $9.29 | $6K | |
| Michael Gray - Officer | Grant or award | Common Stock | 30,500 | $0.00 | - | |
| Michael Gray - Officer | Grant or award | Stock Option (Right to Buy) | 91,500 | $0.00 | - | |
| Aaron Deykin - Officer | Grant or award | Common Stock | 32,000 | $0.00 | - | |
| Aaron Deykin - Officer | Grant or award | Stock Option (Right to Buy) | 96,000 | $0.00 | - | |
| Allison Ambrose - Officer | Grant or award | Common Stock | 17,000 | $0.00 | - | |
| Allison Ambrose - Officer | Grant or award | Stock Option (Right to Buy) | 51,000 | $0.00 | - | |
| Adam Houghton - Officer | Grant or award | Common Stock | 25,000 | $0.00 | - | |
| Adam Houghton - Officer | Grant or award | Stock Option (Right to Buy) | 75,000 | $0.00 | - | |
| Everett Rand Sutherland - Officer | Grant or award | Common Stock | 75,000 | $0.00 | - | |
| Everett Rand Sutherland - Officer | Grant or award | Stock Option (Right to Buy) | 225,000 | $0.00 | - | |
| Allison Ambrose - Officer | Grant or award | Stock Option (Right to Buy) | 100,000 | $0.00 | - | |
| Erez Chimovits - Director | Other | Common Stock | 721,956 | - | - | |
| Erez Chimovits - Director | Open-market purchase | Common Stock | 165,000 | $17.00 | $2.81M | |
| Erez Chimovits - Director | Other | Common Stock | 2,887,833 | - | - | |
| Erez Chimovits - Director | Open-market purchase | Common Stock | 660,000 | $17.00 | $11.22M | |
| Erez Chimovits - Director | Other | Series A redeemable convertible preferred stock | 524,500 | - | - | |
| Erez Chimovits - Director | Other | Series A redeemable convertible preferred stock | 2,098,000 | - | - | |
| Erez Chimovits - Director | Other | Series B redeemable convertible preferred stock | 197,456 | - | - | |
| Erez Chimovits - Director | Other | Series B redeemable convertible preferred stock | 789,833 | - | - | |
| ORBIMED ADVISORS LLC - Director | Other | Common Stock | 721,956 | - | - | |
| ORBIMED ADVISORS LLC - Director | Open-market purchase | Common Stock | 165,000 | $17.00 | $2.81M | |
| ORBIMED ADVISORS LLC - Director | Other | Common Stock | 2,887,833 | - | - | |
| ORBIMED ADVISORS LLC - Director | Open-market purchase | Common Stock | 660,000 | $17.00 | $11.22M | |
| ORBIMED ADVISORS LLC - Director | Other | Series A redeemable convertible preferred stock | 524,500 | - | - | |
| ORBIMED ADVISORS LLC - Director | Other | Series A redeemable convertible preferred stock | 2,098,000 | - | - | |
| ORBIMED ADVISORS LLC - Director | Other | Series B redeemable convertible preferred stock | 197,456 | - | - | |
| ORBIMED ADVISORS LLC - Director | Other | Series B redeemable convertible preferred stock | 789,833 | - | - | |
| AI Upstream LLC | Open-market purchase | Common Stock | 1,175,000 | $17.00 | $19.98M | |
| AI Upstream LLC | Other | Common Stock | 3,147,000 | - | - | |
| AI Upstream LLC | Other | Common Stock | 1,172,410 | - | - | |
| AI Upstream LLC | Other | Series A Convertible Preferred Stock | 3,147,000 | - | - | |
| AI Upstream LLC | Other | Series B Convertible Preferred Stock | 1,172,410 | - | - |
Item 7.01, 8.01, 9.01
Item 2.02, 9.01
Item 5.07
Item 2.02, 9.01
UPB insider trading FAQ
What is the latest insider trade for UPB?
Upstream Bio, Inc. (UPB) had 5 insider filings in the last 90 days, with the most recent on 2026-09-17. The full record for UPB runs to 37 Form 4 filings, the earliest from 2024-10-15. InsiderAlpha adds new Form 4, Form 144 and 8-K filings as they arrive from SEC EDGAR.
How many insiders are buying UPB stock?
No insider purchases of UPB were filed in the last 90 days. 5 purchases are on record for this company.
How many insiders are selling UPB stock?
5 insider sales of UPB were filed in the last 90 days, totaling $28K.
Where can I see UPB SEC filings (Form 4, 10-K, 10-Q, 8-K)?
This page collects UPB Form 4 insider transactions, Form 144 sale notices and 8-K filings in one place. Annual 10-K and quarterly 10-Q reports live on the company's SEC EDGAR page.
More Health Care companies with insider activity
Recent insider filings
10The EDGAR links open each original Form 4, so you can check any number on this page against the filing it came from.
- - Michael Gray view on EDGAR
- - Allison Ambrose view on EDGAR
- - Aaron Deykin view on EDGAR
- - Everett Rand Sutherland view on EDGAR
- - Adam Houghton view on EDGAR
- - Michael Gray view on EDGAR
- - Everett Rand Sutherland view on EDGAR
- - Adam Houghton view on EDGAR
- - Aaron Deykin view on EDGAR
Related companies with recent insider activity
Learn more
- Insider selling: signal or noise?
- Why most insider sales are routine, and the few patterns worth a second look.
- Insider activity in Health Care
- Where UPB's peers are being bought and sold.
- Every recent Form 4
- The market-wide feed, updated as filings arrive from SEC EDGAR.
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