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Spyre Therapeutics, Inc. (SYRE) XNAS PHARMACEUTICAL PREPARATIONS Net insider selling (90d)
Latest SYRE Insider Trades
About Spyre Therapeutics, Inc. (SYRE) Spyre Therapeutics Inc is a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (IBD) and rheumatic diseases. Spyre's pipeline includes extended half-life antibodies targeting α4β7, TL1A, and IL-23 in development as monotherapies and pair-wise combinations. It has a single reportable segment, which is the development of biopharmaceutical products for the treatment of patients with IBD and other immune-mediated disease.
Headquarters WALTHAM, MA
Employees 112
Listed 2016
Exchange XNAS https://www.spyre.com SEC filings for SYRE on EDGAR
90-Day SEC Filing Activity Form 4 transaction type Transactions Shares Total value Open-market sale 29 4,826,948 $412.44M Option exercise 14 118,334 Other acquisition / disposition 2 683,347
SYRE Insider Transactions (Form 4) 93 35 Form 4 filings on record, the earliest from Oct 1, 2024, newest first. Filing history page 1 of 2.
Date Insider Transaction Security Shares Price Value Aug 7, 2026 JA Jeffrey W. Albers - Director Option exercise Common Stock
Recent SYRE Form 8-K Filings 5
Recent SYRE Form 144 Notices of Proposed Sale 3 A Form 144 is notice of an INTENDED sale, not a completed one. It often precedes the Form 4 that reports the trade actually happening.
Filed Filer Relationship Shares Market value Notice Aug 7, 2026 JEFFREY ALBERS Director 5,000 $517K View on EDGAR Aug 7, 2026 SESSIONS, LLC Director
SYRE Insider Trading - FAQ
What is the latest insider trade for SYRE? Spyre Therapeutics, Inc. (SYRE) had 12 insider filings in the last 90 days, with the most recent on 2026-08-11. The full record for SYRE runs to 35 Form 4 filings, the earliest from 2024-10-01. InsiderAlpha tracks every Form 4, Form 144, and 8-K filing in real time.
How many insiders are buying SYRE stock? No insider purchases of SYRE were filed in the last 90 days.
How many insiders are selling SYRE stock? 29 insider sales of SYRE were filed in the last 90 days, totaling $412.44M.
Where can I see SYRE SEC filings (Form 4, 10-K, 10-Q, 8-K)? This page tracks SYRE Form 4 insider transactions, Form 144 sale notices, and 8-K material event disclosures in one timeline. Annual 10-K and quarterly 10-Q reports live on the company's SEC EDGAR page.
How can I follow SYRE insider buys? Create a free InsiderAlpha account and press Watch on this page to add SYRE to your watchlist. A free account also opens the full scored daily plan with every past day and 3 months of price history. No card is required. Sign up at https://insideralpha.ai/register.
More Health Care Companies with Insider Activity Every Form 4 below links to the original document on SEC EDGAR, so the numbers on this page can be checked against the filing they came from.
Related Companies - Recent Insider Activity What is SEC Form 4? The filing insiders must submit within two business days of a trade, and how to read its transaction codes. Track SYRE insider activity as it files Real-time Form 4 alerts, AI-scored daily trade ideas and 10b5-1 plan flags.
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Market cap $7.97B
P/E ratio -
Dividend yield -
Average volume 1.29M
52 week high $110.18
52 week low $14.51
Today's high $93.39
Today's low $89.45
Open $91.75
Volume 1.27M
Previous close $93.62
Shares outstanding 88.17M Market cap
$7.97B
112 employees
SYRE Insider Sentiment - Last 90 Days Share of open-market insider dollar volume that was buying versus selling, from SEC Form 4 filings.
0% Buying 100% Selling
0 insider purchases totaling $0 against 29 sales totaling $412.44M.
Most-Active SYRE Insiders - Last 90 Days 9 Dollar totals are shown for open-market purchases and sales only. Grants, option exercises, gifts and tax withholding are reported by share count because they are not trades at a market price.
Aug 7, 2026 JA Jeffrey W. Albers - Director Open-market sale Common Stock 5,000 $104.47 $522K
Aug 7, 2026 JA Jeffrey W. Albers - Director Open-market sale Common Stock 8,000 $104.38 $835K
Aug 7, 2026 JA Jeffrey W. Albers - Director Open-market sale Common Stock 10,000 $104.68 $1.05M
Aug 7, 2026 JA Jeffrey W. Albers - Director Option exercise Stock Option (Right to Buy) 5,000 $0.00 -
Aug 3, 2026 SB Scott L. Burrows - Officer Option exercise Common Stock 7,500 $14.50 $109K
Aug 3, 2026 SB Scott L. Burrows - Officer Open-market sale Common Stock 5,100 $95.21 $486K
Aug 3, 2026 SB Scott L. Burrows - Officer Open-market sale Common Stock 2,300 $96.30 $221K
Aug 3, 2026 SB Scott L. Burrows - Officer Open-market sale Common Stock 100 $97.10 $10K
Aug 3, 2026 SB Scott L. Burrows - Officer Option exercise Stock Option (Right to Buy) 7,500 $0.00 -
Aug 3, 2026 CT Cameron Turtle - Officer Open-market sale Common Stock 800 $93.97 $75K
Aug 3, 2026 CT Cameron Turtle - Officer Open-market sale Common Stock 7,157 $95.10 $681K
Aug 3, 2026 CT Cameron Turtle - Officer Open-market sale Common Stock 5,635 $95.93 $541K
Aug 3, 2026 CT Cameron Turtle - Officer Open-market sale Common Stock 1,392 $96.82 $135K
Aug 3, 2026 CT Cameron Turtle - Officer Open-market sale Common Stock 16 $97.46 $2K
Jul 1, 2026 SB Scott L. Burrows - Officer Option exercise Common Stock 7,500 $14.50 $109K
Jul 1, 2026 SB Scott L. Burrows - Officer Open-market sale Common Stock 5,775 $87.55 $506K
Jul 1, 2026 SB Scott L. Burrows - Officer Open-market sale Common Stock 1,725 $88.37 $152K
Jul 1, 2026 SB Scott L. Burrows - Officer Option exercise Stock Option (Right to Buy) 7,500 $0.00 -
Jul 1, 2026 SS Sheldon Sloan - Officer Option exercise Common Stock 8,334 $27.46 $229K
Jul 1, 2026 SS Sheldon Sloan - Officer Open-market sale Common Stock 6,500 $87.52 $569K
Jul 1, 2026 SS Sheldon Sloan - Officer Open-market sale Common Stock 1,834 $88.34 $162K
Jul 1, 2026 SS Sheldon Sloan - Officer Option exercise Stock Option (Right to Buy) 8,334 $0.00 -
Jul 1, 2026 CT Cameron Turtle - Officer Open-market sale Common Stock 10,176 $87.44 $890K
Jul 1, 2026 CT Cameron Turtle - Officer Open-market sale Common Stock 4,234 $88.12 $373K
Jul 1, 2026 CT Cameron Turtle - Officer Open-market sale Common Stock 590 $88.91 $52K
Jun 25, 2026 SB Scott L. Burrows - Officer Open-market sale Common Stock 10,000 $87.14 $871K
Jun 25, 2026 SB Scott L. Burrows - Officer Option exercise Stock Option (Right to Buy) 15,000 $0.00 -
Jun 25, 2026 SB Scott L. Burrows - Officer Option exercise Common Stock 15,000 $14.50 $218K
Jun 25, 2026 SB Scott L. Burrows - Officer Open-market sale Common Stock 5,000 $87.12 $436K
Jun 3, 2026 SS Sheldon Sloan - Officer Option exercise Common Stock 8,333 $27.46 $229K
Jun 3, 2026 SS Sheldon Sloan - Officer Open-market sale Common Stock 8,333 $75.00 $625K
Jun 3, 2026 SS Sheldon Sloan - Officer Option exercise Stock Option (Right to Buy) 8,333 $0.00 -
Jun 1, 2026 CT Cameron Turtle - Officer Open-market sale Common Stock 3,557 $69.40 $247K
Jun 1, 2026 CT Cameron Turtle - Officer Open-market sale Common Stock 8,149 $70.50 $575K
Jun 1, 2026 CT Cameron Turtle - Officer Open-market sale Common Stock 3,294 $71.38 $235K
Jun 1, 2026 SB Scott L. Burrows - Officer Option exercise Common Stock 7,500 $14.50 $109K
Jun 1, 2026 SB Scott L. Burrows - Officer Open-market sale Common Stock 1,801 $69.75 $126K
Jun 1, 2026 SB Scott L. Burrows - Officer Open-market sale Common Stock 2,599 $70.77 $184K
Jun 1, 2026 SB Scott L. Burrows - Officer Open-market sale Common Stock 3,100 $72.06 $223K
Jun 1, 2026 SB Scott L. Burrows - Officer Option exercise Stock Option (Right to Buy) 7,500 $0.00 -
May 27, 2026 JA Jeffrey W. Albers - Director Grant or award Stock Option (Right to Buy) 8,026 $0.00 -
May 27, 2026 LS Laurie Stelzer - Director Grant or award Stock Option (Right to Buy) 8,026 $0.00 -
May 27, 2026 MM Mark C. McKenna - Director Grant or award Stock Option (Right to Buy) 8,026 $0.00 -
May 27, 2026 SM Sandra Milligan - Director Grant or award Stock Option (Right to Buy) 8,026 $0.00 -
May 1, 2026 SB Scott L. Burrows - Officer Option exercise Common Stock 12,500 $14.50 $181K
May 1, 2026 SB Scott L. Burrows - Officer Open-market sale Common Stock 12,500 $71.37 $892K
May 1, 2026 SB Scott L. Burrows - Officer Option exercise Stock Option (Right to Buy) 12,500 $0.00 -
May 1, 2026 SS Sheldon Sloan - Officer Option exercise Common Stock 78,333 $27.46 $2.15M
May 1, 2026 SS Sheldon Sloan - Officer Open-market sale Common Stock 21,306 $69.53 $1.48M
May 1, 2026 SS Sheldon Sloan - Officer Open-market sale Common Stock 19,656 $70.61 $1.39M
May 1, 2026 SS Sheldon Sloan - Officer Open-market sale Common Stock 8,777 $71.56 $628K
May 1, 2026 SS Sheldon Sloan - Officer Open-market sale Common Stock 12,777 $72.94 $932K
May 1, 2026 SS Sheldon Sloan - Officer Open-market sale Common Stock 10,358 $73.74 $764K
May 1, 2026 SS Sheldon Sloan - Officer Open-market sale Common Stock 5,059 $74.60 $377K
May 1, 2026 SS Sheldon Sloan - Officer Open-market sale Common Stock 400 $75.37 $30K
May 1, 2026 SS Sheldon Sloan - Officer Option exercise Stock Option (Right to Buy) 78,333 $0.00 -
May 1, 2026 CT Cameron Turtle - Officer Open-market sale Common Stock 5,300 $69.54 $369K
May 1, 2026 CT Cameron Turtle - Officer Open-market sale Common Stock 3,600 $70.77 $255K
May 1, 2026 CT Cameron Turtle - Officer Open-market sale Common Stock 1,000 $71.76 $72K
May 1, 2026 CT Cameron Turtle - Officer Open-market sale Common Stock 3,100 $73.14 $227K
May 1, 2026 CT Cameron Turtle - Officer Open-market sale Common Stock 1,700 $74.23 $126K
May 1, 2026 CT Cameron Turtle - Officer Open-market sale Common Stock 300 $74.96 $22K
Apr 1, 2026 CT Cameron Turtle - Officer Open-market sale Common Stock 12,344 $49.20 $607K
Apr 1, 2026 CT Cameron Turtle - Officer Open-market sale Common Stock 2,656 $49.92 $133K
Apr 1, 2026 SS Sheldon Sloan - Officer Option exercise Common Stock 7,958 $21.66 $172K
Apr 1, 2026 SS Sheldon Sloan - Officer Open-market sale Common Stock 7,958 $50.00 $398K
Apr 1, 2026 SS Sheldon Sloan - Officer Option exercise Stock Option (Right to Buy) 7,958 $0.00 -
Apr 1, 2026 SB Scott L. Burrows - Officer Option exercise Common Stock 7,500 $14.50 $109K
Apr 1, 2026 SB Scott L. Burrows - Officer Open-market sale Common Stock 6,200 $49.21 $305K
Apr 1, 2026 SB Scott L. Burrows - Officer Open-market sale Common Stock 1,300 $49.98 $65K
Apr 1, 2026 SB Scott L. Burrows - Officer Option exercise Stock Option (Right to Buy) 7,500 $0.00 -
Mar 3, 2026 SB Scott L. Burrows - Officer Open-market sale Common Stock 2,300 $40.56 $93K
Mar 3, 2026 SB Scott L. Burrows - Officer Option exercise Stock Option (Right to Buy) 2,500 $0.00 -
Mar 3, 2026 SB Scott L. Burrows - Officer Option exercise Common Stock 2,500 $14.50 $36K
Mar 2, 2026 CT Cameron Turtle - Officer Open-market sale Common Stock 5,900 $41.73 $246K
Mar 2, 2026 CT Cameron Turtle - Officer Open-market sale Common Stock 9,100 $42.49 $387K
Feb 2, 2026 CT Cameron Turtle - Officer Open-market sale Common Stock 957 $31.82 $30K
Feb 2, 2026 CT Cameron Turtle - Officer Open-market sale Common Stock 14,043 $32.87 $462K
Dec 1, 2025 CT Cameron Turtle - Officer Open-market sale Common Stock 10,995 $28.73 $316K
Dec 1, 2025 CT Cameron Turtle - Officer Open-market sale Common Stock 4,005 $29.83 $119K
TCR $IONS
IONIS PHARMACEUTICALS INC
Jeffrey W. Albers - DirectorOpen-market sale$522K
