Macrogenics Inc is a clinical-stage biopharmaceutical company focused on developing antibody-based therapeutics for the treatment of cancer. The company is currently developing therapeutics utilizing multiple modalities, including antibody-drug conjugates (ADCs) and multi-specific antibodies (which it refers to as DART and TRIDENT molecules). It is advancing three proprietary product candidates in clinical development: lorigerlimab, a bispecific DART molecule that targets checkpoint inhibitors PD-1 and CTLA-4; MGC026, an ADC that targets B7-H3 and delivers a novel topoisomerase I inhibitor (TOP1i)-based linker-payload, and MGC028, an ADC that targets ADAM9 and delivers a novel TOP1i-based linker-payload. Its segment is developing and commercializing monoclonal antibody-based therapeutics.
| Form 4 transaction type | Transactions | Shares | Total value |
|---|---|---|---|
| Open-market sale | 1 | 31,105 | $129K |
| Option exercise | 2 | 80,000 |
Dollar totals are shown for open-market purchases and sales only. Grants, option exercises, gifts and tax withholding are reported by share count because they are not trades at a market price.
41 Form 4 filings on record, the earliest from Oct 9, 2024, newest first. Filing history page 1 of 2.
| Date | Insider | Transaction | Security | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Open-market sale | Common Stock | 31,105 | $4.15 | $129K | ||
| Ezio Bonvini - Officer | Option exercise | Common Stock | 40,000 | $2.60 | $104K | |
| Ezio Bonvini - Officer | Option exercise | Employee Stock Option (right to buy) | 40,000 | $2.60 | $104K | |
| Federica F. O'Brien - Director | Option exercise | Common Stock | 3,750 | - | - | |
| Federica F. O'Brien - Director | Option exercise | Restricted Stock Unit | 3,750 | $0.00 | - | |
| Federica F. O'Brien - Director | Grant or award | Stock Option (right to buy) | 22,000 | $0.00 | - | |
| Federica F. O'Brien - Director | Grant or award | Restricted Stock Unit | 3,750 | $0.00 | - | |
| Scott Thomas Jackson - Director | Option exercise | Common Stock | 3,750 | - | - | |
| Scott Thomas Jackson - Director | Option exercise | Restricted Stock Unit | 3,750 | $0.00 | - | |
| Scott Thomas Jackson - Director | Grant or award | Restricted Stock Unit | 3,750 | $0.00 | - | |
| Scott Thomas Jackson - Director | Grant or award | Stock Option (right to buy) | 22,000 | $0.00 | - | |
| Option exercise | Common Stock | 3,750 | - | - | ||
| Option exercise | Restricted Stock Unit | 3,750 | $0.00 | - | ||
| Grant or award | Restricted Stock Unit | 3,750 | $0.00 | - | ||
| Grant or award | Stock Option (right to buy) | 22,000 | $0.00 | - | ||
| Jay Philip Siegel - Director | Option exercise | Common Stock | 3,750 | - | - | |
| Jay Philip Siegel - Director | Option exercise | Restricted Stock Unit | 3,750 | $0.00 | - | |
| Margaret Liu - Director | Option exercise | Common Stock | 3,750 | - | - | |
| Margaret Liu - Director | Option exercise | Restricted Stock Unit | 3,750 | $0.00 | - | |
| Margaret Liu - Director | Grant or award | Restricted Stock Unit | 3,750 | $0.00 | - | |
| Margaret Liu - Director | Grant or award | Stock Option (right to buy) | 22,000 | $0.00 | - | |
| Meenu Chhabra - Director | Option exercise | Common Stock | 3,750 | - | - | |
| Meenu Chhabra - Director | Grant or award | Stock Option (right to buy) | 22,000 | $0.00 | - | |
| Meenu Chhabra - Director | Grant or award | Restricted Stock Unit | 3,750 | $0.00 | - | |
| Meenu Chhabra - Director | Option exercise | Restricted Stock Unit | 3,750 | $0.00 | - | |
| Edward Hurwitz - Director | Option exercise | Common Stock | 3,750 | - | - | |
| Edward Hurwitz - Director | Option exercise | Restricted Stock Unit | 3,750 | $0.00 | - | |
| Edward Hurwitz - Director | Grant or award | Restricted Stock Unit | 3,750 | $0.00 | - | |
| Edward Hurwitz - Director | Grant or award | Stock Option (right to buy) | 22,000 | $0.00 | - | |
| David C. Stump - Director | Option exercise | Common Stock | 3,750 | - | - | |
| David C. Stump - Director | Option exercise | Restricted Stock Unit | 3,750 | $0.00 | - | |
| David C. Stump - Director | Grant or award | Restricted Stock Unit | 3,750 | $0.00 | - | |
| David C. Stump - Director | Grant or award | Stock Option (right to buy) | 22,000 | $0.00 | - | |
| Karen Jean Ferrante - Director | Option exercise | Common Stock | 3,750 | - | - | |
| Karen Jean Ferrante - Director | Option exercise | Restricted Stock Unit | 3,750 | $0.00 | - | |
| Karen Jean Ferrante - Director | Grant or award | Restricted Stock Unit | 3,750 | $0.00 | - | |
| Karen Jean Ferrante - Director | Grant or award | Stock Option (right to buy) | 22,000 | $0.00 | - | |
| Grant or award | Restricted Stock Unit | 3,750 | $0.00 | - | ||
| Grant or award | Stock Option (right to buy) | 22,000 | $0.00 | - | ||
| Ezio Bonvini - Officer | Tax withholding / forfeiture | Common Stock | 6,433 | $1.71 | $11K | |
| Ezio Bonvini - Officer | Option exercise | Common Stock | 16,665 | - | - | |
| Ezio Bonvini - Officer | Option exercise | Restricted Stock Unit | 16,665 | $0.00 | - | |
| Ezio Bonvini - Officer | Grant or award | Restricted Stock Unit | 31,250 | $0.00 | - | |
| Ezio Bonvini - Officer | Grant or award | Employee Stock Option (right to buy) | 187,500 | $0.00 | - | |
| Beth Ann Smith - Officer | Tax withholding / forfeiture | Common Stock | 423 | $1.71 | $723 | |
| Beth Ann Smith - Officer | Option exercise | Common Stock | 1,095 | - | - | |
| Beth Ann Smith - Officer | Option exercise | Restricted Stock Unit | 1,095 | $0.00 | - | |
| Beth Ann Smith - Officer | Grant or award | Restricted Stock Unit | 15,625 | $0.00 | - | |
| Beth Ann Smith - Officer | Grant or award | Employee Stock Option (right to buy) | 93,750 | $0.00 | - | |
| James Karrels - Officer | Option exercise | Common Stock | 14,999 | - | - | |
| James Karrels - Officer | Tax withholding / forfeiture | Common Stock | 5,790 | $1.71 | $10K | |
| James Karrels - Officer | Option exercise | Restricted Stock Unit | 14,999 | $0.00 | - | |
| James Karrels - Officer | Grant or award | Employee Stock Option (right to buy) | 150,000 | $0.00 | - | |
| James Karrels - Officer | Grant or award | Restricted Stock Unit | 25,000 | $0.00 | - | |
| Tax withholding / forfeiture | Common Stock | 5,147 | $1.71 | $9K | ||
| Option exercise | Common Stock | 13,332 | - | - | ||
| Option exercise | Restricted Stock Unit | 13,332 | $0.00 | - | ||
| Grant or award | Employee Stock Option (right to buy) | 150,000 | $0.00 | - | ||
| Grant or award | Restricted Stock Unit | 25,000 | $0.00 | - | ||
| Tax withholding / forfeiture | Common Stock | 5,520 | $1.71 | $9K | ||
| Option exercise | Common Stock | 13,332 | - | - | ||
| Option exercise | Restricted Stock Unit | 13,332 | $0.00 | - | ||
| Grant or award | Restricted Stock Unit | 25,000 | $0.00 | - | ||
| Grant or award | Employee Stock Option (right to buy) | 150,000 | $0.00 | - | ||
| Eric Blasius Risser - Officer | Tax withholding / forfeiture | Common Stock | 6,433 | $1.71 | $11K | |
| Eric Blasius Risser - Officer | Option exercise | Common Stock | 16,665 | - | - | |
| Eric Blasius Risser - Officer | Option exercise | Restricted Stock Unit | 16,665 | $0.00 | - | |
| Eric Blasius Risser - Officer | Grant or award | Restricted Stock Unit | 100,000 | $0.00 | - | |
| Eric Blasius Risser - Officer | Grant or award | Employee Stock Option (right to buy) | 595,000 | $0.00 | - | |
| Option exercise | Common Stock | 21,165 | $0.00 | - | ||
| Option exercise | Restricted Stock Unit | 21,165 | $0.00 | - | ||
| Option exercise | Common Stock | 15,831 | - | - | ||
| Option exercise | Restricted Stock Unit | 15,831 | $0.00 | - | ||
| Tax withholding / forfeiture | Common Stock | 2,485 | $1.81 | $4K | ||
| Tax withholding / forfeiture | Common Stock | 3,186 | $1.81 | $6K | ||
| Option exercise | Common Stock | 6,001 | - | - | ||
| Option exercise | Common Stock | 8,999 | - | - | ||
| Option exercise | Restricted Stock Unit | 6,001 | $0.00 | - | ||
| Option exercise | Restricted Stock Unit | 8,999 | $0.00 | - | ||
| Beth Ann Smith - Officer | Tax withholding / forfeiture | Common Stock | 1,011 | $1.81 | $2K | |
| Beth Ann Smith - Officer | Tax withholding / forfeiture | Common Stock | 612 | $1.81 | $1K | |
| Beth Ann Smith - Officer | Option exercise | Common Stock | 2,617 | - | - | |
| Beth Ann Smith - Officer | Option exercise | Common Stock | 1,583 | - | - | |
| Beth Ann Smith - Officer | Option exercise | Restricted Stock Unit | 2,617 | $0.00 | - | |
| Beth Ann Smith - Officer | Option exercise | Restricted Stock Unit | 1,583 | $0.00 | - | |
| Eric Blasius Risser - Officer | Tax withholding / forfeiture | Common Stock | 2,575 | $1.81 | $5K | |
| Eric Blasius Risser - Officer | Tax withholding / forfeiture | Common Stock | 4,311 | $1.81 | $8K | |
| Eric Blasius Risser - Officer | Option exercise | Common Stock | 6,668 | - | - | |
| Eric Blasius Risser - Officer | Option exercise | Common Stock | 11,166 | - | - | |
| Eric Blasius Risser - Officer | Option exercise | Restricted Stock Unit | 6,668 | $0.00 | - | |
| Eric Blasius Risser - Officer | Option exercise | Restricted Stock Unit | 11,166 | $0.00 | - | |
| Tax withholding / forfeiture | Common Stock | 2,317 | $1.81 | $4K | ||
| Tax withholding / forfeiture | Common Stock | 3,474 | $1.81 | $6K | ||
| Option exercise | Common Stock | 6,001 | - | - | ||
| Option exercise | Common Stock | 8,999 | - | - | ||
| Option exercise | Restricted Stock Unit | 6,001 | $0.00 | - | ||
| Option exercise | Restricted Stock Unit | 8,999 | $0.00 | - | ||
| James Karrels - Officer | Option exercise | Common Stock | 6,334 | - | - | |
| James Karrels - Officer | Tax withholding / forfeiture | Common Stock | 2,446 | $1.81 | $4K | |
| James Karrels - Officer | Option exercise | Common Stock | 9,999 | - | - | |
| James Karrels - Officer | Tax withholding / forfeiture | Common Stock | 3,860 | $1.81 | $7K | |
| James Karrels - Officer | Option exercise | Restricted Stock Unit | 6,334 | $0.00 | - | |
| James Karrels - Officer | Option exercise | Restricted Stock Unit | 9,999 | $0.00 | - | |
| Ezio Bonvini - Officer | Tax withholding / forfeiture | Common Stock | 2,703 | $1.81 | $5K | |
| Ezio Bonvini - Officer | Tax withholding / forfeiture | Common Stock | 4,311 | $1.81 | $8K | |
| Ezio Bonvini - Officer | Option exercise | Common Stock | 7,001 | - | - | |
| Ezio Bonvini - Officer | Option exercise | Common Stock | 11,166 | - | - | |
| Ezio Bonvini - Officer | Option exercise | Restricted Stock Unit | 7,001 | $0.00 | - | |
| Ezio Bonvini - Officer | Option exercise | Restricted Stock Unit | 11,166 | $0.00 | - | |
| Open-market purchase | Common Stock | 50,500 | $1.52 | $77K | ||
| Open-market purchase | Common Stock | 49,500 | $1.49 | $74K | ||
| Grant or award | Employee Stock Option (right to buy) | 30,000 | $0.00 | - | ||
| Grant or award | Employee Stock Option (right to buy) | 30,000 | $0.00 | - | ||
| Option exercise | Common Stock | 21,165 | $0.00 | - | ||
| Option exercise | Common Stock | 31,664 | $0.00 | - | ||
| Option exercise | Restricted Stock Unit | 21,165 | $0.00 | - | ||
| Option exercise | Restricted Stock Unit | 31,664 | $0.00 | - |
A Form 144 is notice of an INTENDED sale, not a completed one. It often precedes the Form 4 that reports the trade actually happening.
| Filed | Filer | Relationship | Shares | Market value | Notice |
|---|---|---|---|---|---|
| Jeffrey Peters | Officer | 31,105 | $129K | View on EDGAR | |
| Jay Siegel | Former Director | 42,080 | $176K | View on EDGAR | |
| Jay Siegel | Former Director | 34,916 | $131K | View on EDGAR |
MACROGENICS INC (MGNX) had 2 insider filings in the last 90 days, with the most recent on 2026-08-20. The full record for MGNX runs to 41 Form 4 filings, the earliest from 2024-10-09. InsiderAlpha tracks every Form 4, Form 144, and 8-K filing in real time.
No insider purchases of MGNX were filed in the last 90 days. 2 purchases are on record for this company.
1 insider sale of MGNX was filed in the last 90 days, totaling $129K.
This page tracks MGNX Form 4 insider transactions, Form 144 sale notices, and 8-K material event disclosures in one timeline. Annual 10-K and quarterly 10-Q reports live on the company's SEC EDGAR page.
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Every Form 4 below links to the original document on SEC EDGAR, so the numbers on this page can be checked against the filing they came from.
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