Amylyx Pharmaceuticals, Inc. (AMLX)

Data as of Oct 7, 2026, from SEC Form 4 filings.

XNASPHARMACEUTICAL PREPARATIONSNet insider selling (90d)Watch AMLX

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Latest AMLX insider trades

George M. Milne Jr. - Director
Open-market sale$831K
Oct 5, 2026
Camille L. Bedrosian - Officer
Open-market sale

About Amylyx Pharmaceuticals, Inc. (AMLX)

Amylyx Pharmaceuticals Inc is a clinical-stage pharmaceutical company focused on developing novel therapies for communities with high unmet medical needs. The company has preclinical and clinical development programs in endocrine conditions and neurodegenerative diseases. Its pipeline includes investigational therapies matched with diseases based on mechanistic rationale, clinical outcomes, biomarkers, and preclinical data. The company is currently developing avexitide for Post-Bariatric Hypoglycemia, AMX0035 for Wolfram Syndrome, AMX0114 for Amyotrophic Lateral Sclerosis, and AMX0318 for Post-Bariatric Hypoglycemia and other rare diseases.

Headquarters: CAMBRIDGE, MA
Employees: 136
Listed: 2022
Exchange: XNAS
Sector: Health Care

https://www.amylyx.com SEC filings for AMLX on EDGAR

AMLX Form 4 activity by transaction type, last 90 days

Form 4 transaction type	Transactions	Shares	Total value
Open-market sale	11	121,302	$3.78M
Grant or award	5	186,976
Option exercise	4	100,000

Dollar totals cover purchases and sales only (codes P and S). Grants, option exercises, gifts and tax withholding are counted in shares, because none of them is a trade at a market price.

AMLX insider transactions (Form 4)

56 Form 4 filings on record, the earliest from Oct 2, 2024, newest first. Filing history page 2 of 2.

Date	Insider	Transaction	Security	Shares	Price	Value
Feb 2, 2026	James M. Frates - Officer	Open-market sale	Common Stock	3,557^{footnote F1}	$14.65^{footnote F2}	$52K
Footnote F1 (shares): Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person. Footnote F2 (price): The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $14.460 to $14.790. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.
Feb 2, 2026	Joshua B. Cohen - Officer	Open-market sale	Common Stock	15,500^{footnote F1}	$14.68^{footnote F2}	$228K
Footnote F1 (shares): Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person. Footnote F2 (price): The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $14.510 to $14.760. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.
Feb 2, 2026	Gina Mazzariello - Officer	Open-market sale	Common Stock	3,448^{footnote F1}	$14.65^{footnote F2}	$51K
Footnote F1 (shares): Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person. Footnote F2 (price): The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $14.470 to $14.810. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.
Feb 2, 2026	Justin B. Klee - Officer	Open-market sale	Common Stock	15,500^{footnote F1}	$14.69^{footnote F2}	$228K
Footnote F1 (shares): Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person. Footnote F2 (price): The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $14.510 to $14.760. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.
Jan 15, 2026	Joshua B. Cohen - Officer	Option exercise	Common Stock	197,182	$7.57	$1.49M
Jan 16, 2026	Joshua B. Cohen - Officer	Option exercise	Common Stock	2,818	$7.57	$21K
Jan 15, 2026	Joshua B. Cohen - Officer	Open-market sale	Common Stock	136,193	$13.59^{footnote F2}	$1.85M
Jan 16, 2026	Joshua B. Cohen - Officer	Open-market sale	Common Stock	1,974	$13.83^{footnote F3}	$27K
Jan 15, 2026	Joshua B. Cohen - Officer	Option exercise	Stock Option (Right to Buy)	197,182	$0.00	-
Jan 16, 2026	Joshua B. Cohen - Officer	Option exercise	Stock Option (Right to Buy)	2,818	$0.00	-
Footnote F2 (price): The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $13.26 to $13.76. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request. Footnote F3 (price): The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $13.82 to $13.835. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.
Jan 15, 2026	Justin B. Klee - Officer	Option exercise	Common Stock	197,153	$7.57	$1.49M
Jan 16, 2026	Justin B. Klee - Officer	Option exercise	Common Stock	2,847	$7.57	$22K
Jan 15, 2026	Justin B. Klee - Officer	Open-market sale	Common Stock	136,193	$13.58^{footnote F2}	$1.85M
Jan 16, 2026	Justin B. Klee - Officer	Open-market sale	Common Stock	1,995	$13.89^{footnote F3}	$28K
Jan 15, 2026	Justin B. Klee - Officer	Option exercise	Stock Option (Right to Buy)	197,153	$0.00	-
Jan 16, 2026	Justin B. Klee - Officer	Option exercise	Stock Option (Right to Buy)	2,847	$0.00	-
Footnote F2 (price): The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $13.26 to $13.77. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request. Footnote F3 (price): The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $13.83 to $13.91. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.
Jan 12, 2026	George M. Milne Jr.	Gift	Common Stock	17,780	$0.00	-
Jan 6, 2026	James M. Frates - Officer	Open-market sale	Common Stock	3,326^{footnote F1}	$11.11^{footnote F2}	$37K
Footnote F1 (shares): Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person. Footnote F2 (price): The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $10.99 to $11.16. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.
Jan 6, 2026	Joshua B. Cohen - Officer	Open-market sale	Common Stock	7,715^{footnote F1}	$11.09^{footnote F2}	$86K
Footnote F1 (shares): Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person. Footnote F2 (price): The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $11.05 to $11.14. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.
Jan 6, 2026	Justin B. Klee - Officer	Open-market sale	Common Stock	7,715^{footnote F1}	$11.09^{footnote F2}	$86K
Footnote F1 (shares): Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person. Footnote F2 (price): The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $10.99 to $11.16. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.
Dec 23, 2025	Karen Firestone	Open-market purchase	Common Stock	8,100	$12.45	$101K
Dec 1, 2025	Camille L. Bedrosian - Officer	Open-market sale	Common Stock	6,580^{footnote F1}	$14.35^{footnote F2}	$94K
Footnote F1 (shares): Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person. Footnote F2 (price): The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $14.30 to $14.42. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.
Sep 30, 2025	Justin B. Klee - Officer	Open-market sale	Common Stock	29,775	$14.37	$428K
Sep 30, 2025	Justin B. Klee - Officer	Open-market sale	Common Stock	200	$15.01	$3K
Sep 30, 2025	Gina Mazzariello - Officer	Open-market sale	Common Stock	8,828	$14.58	$129K
Sep 30, 2025	Joshua B. Cohen - Officer	Open-market sale	Common Stock	29,733	$14.34	$426K
Sep 30, 2025	Joshua B. Cohen - Officer	Open-market sale	Common Stock	200	$15.00	$3K
Sep 30, 2025	Camille L. Bedrosian - Officer	Open-market sale	Common Stock	12,039	$14.58	$176K
Sep 30, 2025	James M. Frates - Officer	Open-market sale	Common Stock	10,558	$14.65	$155K
Aug 12, 2025	Gina Mazzariello - Officer	Open-market sale	Common Stock	15,000	$8.07	$121K
Aug 13, 2025	Gina Mazzariello - Officer	Open-market sale	Common Stock	15,000	$8.34	$125K
Jun 5, 2025	George M. Milne Jr.	Grant or award	Stock Option (right to buy)	25,000	$0.00	-
Mar 31, 2025	James M. Frates - Officer	Open-market sale	Common Stock	10,896	$3.47	$38K
Dec 2, 2024	Camille L. Bedrosian - Officer	Open-market sale	Common Stock	5,421	$5.54	$30K
Nov 4, 2024	Justin B. Klee - Officer	Option exercise	Common Stock	63,690	$1.57	$100K
Nov 4, 2024	Justin B. Klee - Officer	Option exercise	Stock Option (right to buy)	63,690	$0.00	-
Sep 30, 2024	Justin B. Klee - Officer	Open-market sale	Common Stock	18,589	$3.20	$59K
Sep 30, 2024	Joshua B. Cohen - Officer	Open-market sale	Common Stock	18,589	$3.20	$59K
Sep 30, 2024	Gina Mazzariello - Officer	Open-market sale	Common Stock	8,709	$3.20	$28K
Sep 30, 2024	Camille L. Bedrosian - Officer	Open-market sale	Common Stock	11,442	$3.20	$37K

Recent AMLX Form 8-K filings

Read AMLX company news

Sep 8, 2026Item 1.01

Read the filing on SEC EDGAR

Aug 20, 2026Item 1.01, 9.01

Read the filing on SEC EDGAR

Aug 18, 2026Item 7.01, 8.01, 9.01

Read the filing on SEC EDGAR

Aug 18, 2026Item 8.01, 9.01

Recent AMLX Form 144 notices of proposed sale

An insider files Form 144 before selling restricted or control stock. It announces a planned sale. If the sale goes ahead, it shows up later on a Form 4.

Filed	Filer	Relationship	Shares	Market value	Notice
Oct 5, 2026	GEORGE MILNE	Director	100,000	$2.78M	View on EDGAR
Sep 11, 2026	Bedrosian Camille L	Officer	10,028

AMLX insider trading FAQ

What is the latest insider trade for AMLX?

Amylyx Pharmaceuticals, Inc. (AMLX) had 12 insider filings in the last 90 days, with the most recent on 2026-10-07. The full record for AMLX runs to 56 Form 4 filings, the earliest from 2024-10-02. InsiderAlpha adds new Form 4, Form 144 and 8-K filings as they arrive from SEC EDGAR.

How many insiders are buying AMLX stock?

No insider purchases of AMLX were filed in the last 90 days. 2 purchases are on record for this company.

How many insiders are selling AMLX stock?

11 insider sales of AMLX were filed in the last 90 days, totaling $3.78M.

Where can I see AMLX SEC filings (Form 4, 10-K, 10-Q, 8-K)?

This page collects AMLX Form 4 insider transactions, Form 144 sale notices and 8-K filings in one place. Annual 10-K and quarterly 10-Q reports live on the company's SEC EDGAR page.

More Health Care companies with insider activity

Recent insider filings

The EDGAR links open each original Form 4, so you can check any number on this page against the filing it came from.

Oct 7, 2026 - George M. Milne Jr. view on EDGAR
Sep 14, 2026 - Camille L. Bedrosian view on EDGAR
Sep 14, 2026 - James M. Frates view on EDGAR
Sep 14, 2026 - Gina Mazzariello view on EDGAR
Sep 14, 2026 - Justin B. Klee view on EDGAR
Sep 14, 2026 - Joshua B. Cohen view on EDGAR
Sep 2, 2026 - Karen Firestone view on EDGAR
Aug 21, 2026 - James M. Frates view on EDGAR
Aug 21, 2026 - Justin B. Klee view on EDGAR

Related companies with recent insider activity

Learn more

Insider selling: signal or noise?: Why most insider sales are routine, and the few patterns worth a second look.
Form 144 vs Form 4: A Form 144 announces a planned sale; the Form 4 reports it after it happens.
Insider activity in Health Care: Where AMLX's peers are being bought and sold.
Every recent Form 4: The market-wide feed, updated as filings arrive from SEC EDGAR.

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Form 4 transaction type

Transactions

Total value

Open-market sale

121,302

$3.78M

Grant or award

186,976

Option exercise

100,000

Date

Insider

Transaction

Security

Price

Value

Feb 2, 2026

James M. Frates - Officer

Open-market sale

Common Stock

3,557^{footnote F1}

$14.65^{footnote F2}

$52K

Footnote F1 (shares): Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.
Footnote F2 (price): The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $14.460 to $14.790. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Feb 2, 2026

Joshua B. Cohen - Officer

Open-market sale

Common Stock

15,500^{footnote F1}

$14.68^{footnote F2}

$228K

Footnote F1 (shares): Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.
Footnote F2 (price): The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $14.510 to $14.760. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Feb 2, 2026

Gina Mazzariello - Officer

Open-market sale

Common Stock

3,448^{footnote F1}

$14.65^{footnote F2}

$51K

Footnote F1 (shares): Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.
Footnote F2 (price): The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $14.470 to $14.810. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Feb 2, 2026

Justin B. Klee - Officer

Open-market sale

Common Stock

15,500^{footnote F1}

$14.69^{footnote F2}

$228K

Footnote F1 (shares): Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.
Footnote F2 (price): The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $14.510 to $14.760. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Jan 15, 2026

Joshua B. Cohen - Officer

Option exercise

Common Stock

197,182

$7.57

$1.49M

Jan 16, 2026

Joshua B. Cohen - Officer

Option exercise

Common Stock

2,818

$7.57

$21K

Jan 15, 2026

Joshua B. Cohen - Officer

Open-market sale

Common Stock

136,193

$13.59^{footnote F2}

$1.85M

Jan 16, 2026

Joshua B. Cohen - Officer

Open-market sale

Common Stock

1,974

$13.83^{footnote F3}

$27K

Jan 15, 2026

Joshua B. Cohen - Officer

Option exercise

Stock Option (Right to Buy)

197,182

$0.00

Jan 16, 2026

Joshua B. Cohen - Officer

Option exercise

Stock Option (Right to Buy)

2,818

$0.00

Footnote F2 (price): The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $13.26 to $13.76. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.
Footnote F3 (price): The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $13.82 to $13.835. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Jan 15, 2026

Justin B. Klee - Officer

Option exercise

Common Stock

197,153

$7.57

$1.49M

Jan 16, 2026

Justin B. Klee - Officer

Option exercise

Common Stock

2,847

$7.57

$22K

Jan 15, 2026

Justin B. Klee - Officer

Open-market sale

Common Stock

136,193

$13.58^{footnote F2}

$1.85M

Jan 16, 2026

Justin B. Klee - Officer

Open-market sale

Common Stock

1,995

$13.89^{footnote F3}

$28K

Jan 15, 2026

Justin B. Klee - Officer

Option exercise

Stock Option (Right to Buy)

197,153

$0.00

Jan 16, 2026

Justin B. Klee - Officer

Option exercise

Stock Option (Right to Buy)

2,847

$0.00

Footnote F2 (price): The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $13.26 to $13.77. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.
Footnote F3 (price): The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $13.83 to $13.91. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Jan 12, 2026

George M. Milne Jr.

Gift

Common Stock

17,780

$0.00

Jan 6, 2026

James M. Frates - Officer

Open-market sale

Common Stock

3,326^{footnote F1}

$11.11^{footnote F2}

$37K

Footnote F1 (shares): Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.
Footnote F2 (price): The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $10.99 to $11.16. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Jan 6, 2026

Joshua B. Cohen - Officer

Open-market sale

Common Stock

7,715^{footnote F1}

$11.09^{footnote F2}

$86K

Footnote F1 (shares): Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.
Footnote F2 (price): The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $11.05 to $11.14. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Jan 6, 2026

Justin B. Klee - Officer

Open-market sale

Common Stock

7,715^{footnote F1}

$11.09^{footnote F2}

$86K

Footnote F1 (shares): Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.
Footnote F2 (price): The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $10.99 to $11.16. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Dec 23, 2025

Karen Firestone

Open-market purchase

Common Stock

8,100

$12.45

$101K

Dec 1, 2025

Camille L. Bedrosian - Officer

Open-market sale

Common Stock

6,580^{footnote F1}

$14.35^{footnote F2}

$94K

Footnote F1 (shares): Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.
Footnote F2 (price): The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $14.30 to $14.42. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

Sep 30, 2025

Justin B. Klee - Officer

Open-market sale

Common Stock

29,775

$14.37

$428K

Sep 30, 2025

Justin B. Klee - Officer

Open-market sale

Common Stock

200

$15.01

$3K

Sep 30, 2025

Gina Mazzariello - Officer

Open-market sale

Common Stock

8,828

$14.58

$129K

Sep 30, 2025

Joshua B. Cohen - Officer

Open-market sale

Common Stock

29,733

$14.34

$426K

Sep 30, 2025

Joshua B. Cohen - Officer

Open-market sale

Common Stock

200

$15.00

$3K

Sep 30, 2025

Camille L. Bedrosian - Officer

Open-market sale

Common Stock

12,039

$14.58

$176K

Sep 30, 2025

James M. Frates - Officer

Open-market sale

Common Stock

10,558

$14.65

$155K

Aug 12, 2025

Gina Mazzariello - Officer

Open-market sale

Common Stock

15,000

$8.07

$121K

Aug 13, 2025

Gina Mazzariello - Officer

Open-market sale

Common Stock

15,000

$8.34

$125K

Jun 5, 2025

George M. Milne Jr.

Grant or award

Stock Option (right to buy)

25,000

$0.00

Mar 31, 2025

James M. Frates - Officer

Open-market sale

Common Stock

10,896

$3.47

$38K

Dec 2, 2024

Camille L. Bedrosian - Officer

Open-market sale

Common Stock

5,421

$5.54

$30K

Nov 4, 2024

Justin B. Klee - Officer

Option exercise

Common Stock

63,690

$1.57

$100K

Nov 4, 2024

Justin B. Klee - Officer

Option exercise

Stock Option (right to buy)

63,690

$0.00

Sep 30, 2024

Justin B. Klee - Officer

Open-market sale

Common Stock

18,589

$3.20

$59K

Sep 30, 2024

Joshua B. Cohen - Officer

Open-market sale

Common Stock

18,589

$3.20

$59K

Sep 30, 2024

Gina Mazzariello - Officer

Open-market sale

Common Stock

8,709

$3.20

$28K

Sep 30, 2024

Camille L. Bedrosian - Officer

Open-market sale

Common Stock

11,442

$3.20

$37K

Filed

Filer

Relationship

Market value

Notice

Oct 5, 2026

GEORGE MILNE

Director

100,000

$2.78M

View on EDGAR

Sep 11, 2026

Bedrosian Camille L

Officer

10,028