Akari Therapeutics PLC is an oncology company developing next-generation antibody-drug conjugates (ADCs) built around novel, proprietary payloads utilizing powerful biology to attack cancer. Its payload, PH1, targets RNA splicing by modulating the spliceosome, a complex machinery in the cell that converts pre-RNA into spliced RNA for translation into vital proteins for cell survival and growth. Its product pipeline is AKTX-101, which targets the Trop2 receptor on cancer cells and, with a proprietary linker, enables it to deliver its novel PH1 payload directly into the tumor with minimal off-target effects. and AKTX-102, an ADC candidate targeting CEACAM5 (Carcinoembryonic Antigen-related Cell Adhesion Molecule-5), a well-validated tumor antigen expressed across multiple solid tumors.
| Form 4 transaction type | Transactions | Shares | Total value |
|---|---|---|---|
| Grant or award | 11 | 42,751 | |
| Option exercise | 6 | 44,948 |
Dollar totals are shown for open-market purchases and sales only. Grants, option exercises, gifts and tax withholding are reported by share count because they are not trades at a market price.
27 Form 4 filings on record, the earliest from Oct 2, 2024, newest first.
| Date | Insider | Transaction | Security | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Kameel D. Farag - Officer | Grant or award | American Depositary Shares representing Ordinary Shares | 1,728 | $7.52 | $13K | |
| Kameel D. Farag - Officer | Grant or award | American Depositary Shares representing Ordinary Shares | 1,130 | $11.50 | $13K | |
| Samir Rashmikant Patel - Director | Option exercise | American Depositary Shares representing Ordinary Shares | 1,209 | $8.00 | $10K | |
| Samir Rashmikant Patel - Director | Option exercise | American Depositary Shares representing Ordinary Shares | 15,466 | $0.00 | $6 | |
| Samir Rashmikant Patel - Director | Option exercise | American Depositary Shares representing Ordinary Shares | 5,799 | $0.00 | $2 | |
| Samir Rashmikant Patel - Director | Option exercise | Pre-Funded Warrant to purchase American Depositary Shares | 1,209 | $32.00 | $39K | |
| Samir Rashmikant Patel - Director | Option exercise | Pre-Funded Warrant to purchase ADSs | 15,466 | $16.16 | $250K | |
| Samir Rashmikant Patel - Director | Option exercise | Pre-Funded Warrant to purchase ADSs | 5,799 | $16.16 | $94K | |
| Kameel D. Farag - Officer | Grant or award | American Depositary Shares representing Ordinary Shares | 2,539 | $5.12 | $13K | |
| Kameel D. Farag - Officer | Grant or award | American Depositary Shares representing Ordinary Shares | 3,725 | $3.49 | $13K | |
| Kameel D. Farag - Officer | Grant or award | American Depositary Shares representing Ordinary Shares | 7,353 | $3.74 | $28K | |
| Kameel D. Farag - Officer | Grant or award | American Depositary Shares representing Ordinary Shares | 1,000 | $13.00 | $13K | |
| Kameel D. Farag - Officer | Grant or award | American Depositary Shares representing Ordinary Shares | 1,248 | $10.02 | $13K | |
| Kameel D. Farag - Officer | Grant or award | American Depositary Shares representing Ordinary Shares | 1,395 | $9.32 | $13K | |
| Kameel D. Farag - Officer | Grant or award | American Depositary Shares representing Ordinary Shares | 1,570 | $8.28 | $13K | |
| Abizer Gaslightwala - Officer | Grant or award | Stock Option (Right to Buy) | 15,563 | $0.00 | - | |
| Abizer Gaslightwala - Officer | Grant or award | Stock Option (Right to Buy) | 5,500 | $0.00 | - | |
| James R. Neal - Director | Open-market purchase | Warrants to purchase American Depositary Shares ("ADRs") | 2,473 | - | - | |
| James R. Neal - Director | Open-market purchase | Pre-Funded Warrants to purchase ADRs | 2,473 | $16.16 | $999 | |
| James R. Neal - Director | Open-market purchase | Warrants to purchase ADRs | 3,093 | - | - | |
| James R. Neal - Director | Open-market purchase | Pre-Funded Warrants to purchase ADRs | 3,093 | $16.16 | $1K | |
| Raymond Prudo-Chlebosz - Director | Open-market purchase | Warrants to purchase American Depositary Shares ("ADRs") | 618,658 | - | - | |
| Raymond Prudo-Chlebosz - Director | Open-market purchase | Pre-Funded Warrants to purchase ADRs | 618,658 | $16.16 | $250K | |
| Raymond Prudo-Chlebosz - Director | Open-market purchase | Warrants to purchase ADRs | 386,661 | - | - | |
| Raymond Prudo-Chlebosz - Director | Open-market purchase | Pre-Funded Warrants to purchase ADRs | 386,661 | $16.16 | $156K | |
| Sandip I. Patel - Director | Open-market purchase | Warrants to purchase American Depositary Shares ("ADRs") | 247,462 | - | - | |
| Sandip I. Patel - Director | Open-market purchase | Pre-Funded Warrants to purchase ADRs | 247,462 | $16.16 | $100K | |
| Sandip I. Patel - Director | Open-market purchase | Warrants to purchase ADRs | 154,664 | - | - | |
| Sandip I. Patel - Director | Open-market purchase | Pre-Funded Warrants to purchase ADRs | 154,664 | $16.16 | $62K | |
| Hoyoung Huh - Director | Open-market purchase | Warrants to purchase American Depositary Shares ("ADRs") | 618,658 | - | - | |
| Hoyoung Huh - Director | Open-market purchase | Pre-Funded Warrants to purchase ADRs | 618,658 | $16.16 | $250K | |
| Hoyoung Huh - Director | Open-market purchase | Warrants to purchase ADRs | 3,093,293 | - | - | |
| Hoyoung Huh - Director | Open-market purchase | Pre-Funded Warrants to purchase ADRs | 3,093,293 | $16.16 | $1.25M | |
| Kameel D. Farag - Officer | Open-market purchase | Warrants to purchase American Depositary Shares ("ADRs") | 24,745 | - | - | |
| Kameel D. Farag - Officer | Open-market purchase | Pre-Funded Warrants to purchase ADRs | 24,745 | $16.16 | $10K | |
| Samir Rashmikant Patel - Director | Open-market purchase | Warrants to purchase American Depositary Shares ("ADRs") | 618,658 | - | - | |
| Samir Rashmikant Patel - Director | Open-market purchase | Pre-Funded Warrants to purchase ADRs | 618,658 | $16.16 | $250K | |
| Samir Rashmikant Patel - Director | Open-market purchase | Warrants to purchase ADRs | 231,997 | - | - | |
| Samir Rashmikant Patel - Director | Open-market purchase | Pre-Funded Warrants to purchase ADRs | 231,997 | $16.16 | $94K | |
| Abizer Gaslightwala - Officer | Open-market purchase | Warrants to purchase American Depositary Shares ("ADRs") | 309,328 | - | - | |
| Abizer Gaslightwala - Officer | Open-market purchase | Pre-Funded Warrants to purchase ADRs | 309,328 | $16.16 | $125K | |
| Abizer Gaslightwala - Officer | Open-market purchase | Warrants to purchase ADRs | 773,323 | - | - | |
| Abizer Gaslightwala - Officer | Open-market purchase | Pre-Funded Warrants to purchase ADRs | 773,323 | $16.16 | $312K | |
| Robert B. Bazemore - Director | Open-market purchase | Warrants to purchase American Depositary Shares ("ADRs") | 123,731 | - | - | |
| Robert B. Bazemore - Director | Open-market purchase | Pre-Funded Warrants to purchase ADRs | 123,731 | $16.16 | $50K | |
| Robert B. Bazemore - Director | Open-market purchase | Warrants to purchase ADRs | 30,932 | - | - | |
| Robert B. Bazemore - Director | Open-market purchase | Pre-Funded Warrants to purchase ADRs | 30,932 | $16.16 | $12K | |
| Kameel D. Farag - Officer | Grant or award | American Depositary Shares representing Ordinary Shares | 26,619 | $30.00 | $20K | |
| Kameel D. Farag - Officer | Grant or award | American Depositary Shares representing Ordinary Shares | 32,000 | $30.00 | $24K | |
| Kameel D. Farag - Officer | Grant or award | American Depositary Shares representing Ordinary Shares | 6,277 | $29.60 | $5K | |
| Abizer Gaslightwala - Officer | Open-market purchase | American Depositary Shares representing Ordinary Shares | 10,000 | $37.60 | $9K | |
| Abizer Gaslightwala - Officer | Open-market purchase | American Depositary Shares representing Ordinary Shares | 8,000 | $37.20 | $7K | |
| Abizer Gaslightwala - Officer | Open-market purchase | American Depositary Shares representing Ordinary Shares | 3,000 | $36.00 | $3K | |
| Abizer Gaslightwala | Grant or award | Ordinary Shares, par value $0.0001 per share | 40,000,000 | $0.02 | $20K | |
| Samir Rashmikant Patel | Grant or award | Ordinary Shares, par value $0.0001 per share | 3,200,000 | $0.02 | $2K | |
| Samir Rashmikant Patel | Grant or award | Ordinary Shares, par value $0.0001 per share | 400,000 | $0.02 | $200 | |
| Abizer Gaslightwala | Grant or award | Ordinary Shares, par value $0.0001 per share | 30,000,000 | $0.02 | $15K | |
| Samir Rashmikant Patel | Grant or award | Ordinary Shares, par value $0.0001 per share | 7,500,000 | $0.02 | $4K | |
| James R. Neal | Grant or award | Ordinary Shares, par value $0.0001 per share | 2,000,000 | $0.02 | $1K | |
| Samir Rashmikant Patel | Grant or award | Ordinary Shares, par value $0.0001 per share | 1,400,000 | $0.02 | $700 | |
| Samir Rashmikant Patel | Grant or award | Ordinary Shares, par value $0.0001 per share | 419,286,000 | $0.05 | $503K | |
| Samir Rashmikant Patel | Grant or award | Stock Option (Right to Buy) | 162,604,000 | $0.00 | - | |
| Samir Rashmikant Patel | Grant or award | Warrants (Right to Buy) | 419,286,000 | $0.05 | $503K | |
| Raymond Prudo-Chlebosz | Grant or award | Ordinary Shares, par value $0.0001 per share | 419,286,000 | $0.05 | $503K | |
| Raymond Prudo-Chlebosz | Grant or award | Warrants (Right to Buy) | 419,286,000 | $0.05 | $503K | |
| Samir Rashmikant Patel | Grant or award | Ordinary Shares, par value $0.0001 per share | 1,404,622,000 | - | - | |
| Samir Rashmikant Patel | Grant or award | Stock Option (Right to Buy) | 79,684,000 | $0.00 | - | |
| Samir Rashmikant Patel | Grant or award | Stock Option (Right to Buy) | 175,080,000 | $0.00 | - |
Akari Therapeutics Plc (AKTX) had 5 insider filings in the last 90 days, with the most recent on 2026-08-19. The full record for AKTX runs to 27 Form 4 filings, the earliest from 2024-10-02. InsiderAlpha tracks every Form 4, Form 144, and 8-K filing in real time.
No insider purchases of AKTX were filed in the last 90 days. 33 purchases are on record for this company.
No insider sales of AKTX were filed in the last 90 days.
This page tracks AKTX Form 4 insider transactions, Form 144 sale notices, and 8-K material event disclosures in one timeline. Annual 10-K and quarterly 10-Q reports live on the company's SEC EDGAR page.
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Every Form 4 below links to the original document on SEC EDGAR, so the numbers on this page can be checked against the filing they came from.
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