Agios Pharmaceuticals Inc is a biopharmaceutical company focused on the field of cellular metabolism to create differentiated medicines for rare diseases, with a focus on classical hematology. The company's primary focus is to develop potentially transformative small-molecule medicines. Its product candidate, Pyrukynd (mitapivat), is an activator of both wild-type and mutant pyruvate kinase enzymes, developed for the treatment of hemolytic anemias. The other drug candidates in its pipeline include Tebapivat (PK activator), being developed as a potential treatment for MDS-associated anemia and sickle cell disease, AG-181 (PAH stabilizer), AG-236 and others.
| Form 4 transaction type | Transactions | Shares | Total value |
|---|---|---|---|
| Open-market sale | 2 | 34,007 | $1.06M |
| Grant or award | 25 | 216,340 | |
| Option exercise | 29 | 125,157 |
Dollar totals are shown for open-market purchases and sales only. Grants, option exercises, gifts and tax withholding are reported by share count because they are not trades at a market price.
57 Form 4 filings on record, the earliest from Nov 12, 2024, newest first. Filing history page 2 of 2.
| Date | Insider | Transaction | Security | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Option exercise | Common stock | 4,000 | $0.00 | - | ||
| Option exercise | Common stock | 5,666 | $0.00 | - | ||
| Option exercise | Common stock | 4,000 | $0.00 | - | ||
| Open-market sale | Common stock | 1,187 | $28.96 | $34K | ||
| Open-market sale | Common stock | 1,187 | $28.96 | $34K | ||
| Open-market sale | Common stock | 1,681 | $28.96 | $49K | ||
| Grant or award | Restricted stock units | 14,000 | $0.00 | - | ||
| Grant or award | Restricted stock units | 22,000 | $0.00 | - | ||
| Grant or award | Stock options (right to buy) | 52,000 | $0.00 | - | ||
| Option exercise | Restricted stock units | 4,000 | $0.00 | - | ||
| Option exercise | Restricted stock units | 4,000 | $0.00 | - | ||
| Option exercise | Restricted stock units | 5,666 | $0.00 | - | ||
| Option exercise | Common stock | 2,000 | $0.00 | - | ||
| Option exercise | Common stock | 5,666 | $0.00 | - | ||
| Option exercise | Common stock | 4,000 | $0.00 | - | ||
| Option exercise | Common stock | 5,303 | $0.00 | - | ||
| Open-market sale | Common stock | 594 | $28.96 | $17K | ||
| Open-market sale | Common stock | 1,681 | $28.96 | $49K | ||
| Open-market sale | Common stock | 1,187 | $28.96 | $34K | ||
| Open-market sale | Common stock | 1,573 | $28.96 | $46K | ||
| Grant or award | Restricted stock units | 14,000 | $0.00 | - | ||
| Grant or award | Stock options (right to buy) | 52,000 | $0.00 | - | ||
| Option exercise | Restricted stock units | 2,000 | $0.00 | - | ||
| Option exercise | Restricted stock units | 5,666 | $0.00 | - | ||
| Option exercise | Restricted stock units | 4,000 | $0.00 | - | ||
| Option exercise | Restricted stock units | 5,303 | $0.00 | - | ||
| Option exercise | Common stock | 5,666 | $0.00 | - | ||
| Option exercise | Common stock | 4,000 | $0.00 | - | ||
| Open-market sale | Common stock | 1,681 | $28.96 | $49K | ||
| Open-market sale | Common stock | 1,187 | $28.96 | $34K | ||
| Grant or award | Restricted stock units | 14,000 | $0.00 | - | ||
| Grant or award | Stock options (right to buy) | 52,000 | $0.00 | - | ||
| Option exercise | Restricted stock units | 5,666 | $0.00 | - | ||
| Option exercise | Restricted stock units | 4,000 | $0.00 | - | ||
| Theodore James Washburn Jr. - Officer | Option exercise | Common stock | 2,450 | $0.00 | - | |
| Theodore James Washburn Jr. - Officer | Option exercise | Common stock | 2,695 | $0.00 | - | |
| Theodore James Washburn Jr. - Officer | Option exercise | Common stock | 2,350 | $0.00 | - | |
| Theodore James Washburn Jr. - Officer | Open-market sale | Common stock | 698 | $28.96 | $20K | |
| Theodore James Washburn Jr. - Officer | Open-market sale | Common stock | 727 | $28.96 | $21K | |
| Theodore James Washburn Jr. - Officer | Open-market sale | Common stock | 798 | $28.96 | $23K | |
| Theodore James Washburn Jr. - Officer | Grant or award | Restricted stock units | 8,452 | $0.00 | - | |
| Theodore James Washburn Jr. - Officer | Option exercise | Restricted stock units | 2,350 | $0.00 | - | |
| Theodore James Washburn Jr. - Officer | Option exercise | Restricted stock units | 2,450 | $0.00 | - | |
| Theodore James Washburn Jr. - Officer | Option exercise | Restricted stock units | 2,695 | $0.00 | - | |
| Krishnan Viswanadhan - Officer | Grant or award | Restricted stock units | 14,000 | $0.00 | - | |
| Krishnan Viswanadhan - Officer | Grant or award | Stock options (right to buy) | 52,000 | $0.00 | - | |
| David Scadden - Director | Open-market sale | Common stock | 200 | $43.84 | $9K | |
| David Scadden - Director | Option exercise | Stock options (right to buy) | 200 | $0.00 | - | |
| David Scadden - Director | Option exercise | Common stock | 200 | $18.09 | $4K | |
| Option exercise | Stock options (right to buy) | 2,454 | $0.00 | - | ||
| Option exercise | Common stock | 2,454 | $25.01 | $61K | ||
| Open-market sale | Common stock | 2,454 | $43.78 | $107K | ||
| Option exercise | Stock options (right to buy) | 200 | $0.00 | - | ||
| Option exercise | Common stock | 200 | $25.01 | $5K | ||
| Open-market sale | Common stock | 200 | $43.81 | $9K | ||
| Option exercise | Common stock | 3,302 | $25.01 | $83K | ||
| Open-market sale | Common stock | 3,302 | $43.92 | $145K | ||
| Option exercise | Stock options (right to buy) | 3,302 | $0.00 | - | ||
| David Scadden - Director | Option exercise | Common stock | 200 | $18.09 | $4K | |
| David Scadden - Director | Open-market sale | Common stock | 200 | $41.00 | $8K | |
| David Scadden - Director | Option exercise | Stock options (right to buy) | 200 | $0.00 | - | |
| David Scadden - Director | Option exercise | Common stock | 200 | $18.09 | $4K | |
| David Scadden - Director | Open-market sale | Common stock | 200 | $40.00 | $8K | |
| David Scadden - Director | Option exercise | Stock options (right to buy) | 200 | $0.00 | - | |
| Option exercise | Common stock | 7,472 | $0.00 | - | ||
| Open-market sale | Common stock | 3,651 | $36.77 | $134K | ||
| Option exercise | Restricted stock units | 7,472 | $0.00 | - | ||
| Theodore James Washburn Jr. - Officer | Open-market sale | Common stock | 8,546 | $36.87 | $315K | |
| David Scadden - Director | Option exercise | Common stock | 200 | $18.09 | $4K | |
| David Scadden - Director | Open-market sale | Common stock | 200 | $40.00 | $8K | |
| David Scadden - Director | Option exercise | Stock options (right to buy) | 200 | $0.00 | - | |
| Cynthia Smith - Director | Option exercise | Common stock | 2,302 | $0.00 | - | |
| Cynthia Smith - Director | Option exercise | Restricted stock units | 2,302 | $0.00 | - | |
| Option exercise | Common stock | 2,302 | $0.00 | - | ||
| Option exercise | Restricted stock units | 2,302 | $0.00 | - | ||
| Option exercise | Common stock | 22,691 | $0.00 | - | ||
| Open-market sale | Common stock | 11,085 | $36.67 | $406K | ||
| Option exercise | Restricted stock units | 22,691 | $0.00 | - | ||
| David Scadden - Director | Option exercise | Common stock | 1,400 | $18.09 | $25K | |
| David Scadden - Director | Open-market sale | Common stock | 1,400 | $40.00 | $56K | |
| David Scadden - Director | Option exercise | Stock options (right to buy) | 1,400 | $0.00 | - | |
| Option exercise | Common stock | 11,914 | $25.01 | $298K | ||
| Open-market sale | Common stock | 11,067 | $37.93 | $420K | ||
| Open-market sale | Common stock | 847 | $38.76 | $33K | ||
| Option exercise | Stock options (right to buy) | 11,914 | $0.00 | - | ||
| Grant or award | Stock options (right to buy) | 23,393 | $0.00 | - | ||
| Grant or award | Restricted stock units | 4,341 | $0.00 | - | ||
| Option exercise | Common stock | 8,374 | $0.00 | - | ||
| Open-market sale | Common stock | 4,091 | $34.17 | $140K | ||
| Option exercise | Restricted stock units | 8,374 | $0.00 | - | ||
| Option exercise | Common stock | 2,120 | $0.00 | - | ||
| Grant or award | Restricted stock units | 2,861 | $0.00 | - | ||
| Grant or award | Stock options (right to buy) | 15,768 | $0.00 | - | ||
| Option exercise | Restricted stock units | 2,120 | $0.00 | - | ||
| Option exercise | Common stock | 1,977 | $0.00 | - | ||
| Option exercise | Restricted stock units | 1,977 | $0.00 | - | ||
| David Scadden - Director | Option exercise | Common stock | 200 | $18.09 | $4K | |
| David Scadden - Director | Open-market sale | Common stock | 200 | $46.28 | $9K | |
| David Scadden - Director | Option exercise | Stock options (right to buy) | 200 | $0.00 | - | |
| Theodore James Washburn Jr. - Officer | Open-market sale | Common stock | 772 | $56.09 | $43K | |
| James William Burns - Officer | Open-market sale | Common stock | 13,411 | $52.00 | $697K | |
| James William Burns - Officer | Open-market sale | Common stock | 8,341 | $52.56 | $438K | |
| Option exercise | Common stock | 10,000 | $25.99 | $260K | ||
| Open-market sale | Common stock | 8,132 | $53.32 | $434K | ||
| Open-market sale | Common stock | 1,868 | $54.41 | $102K | ||
| Option exercise | Common stock | 10,000 | $25.99 | $260K | ||
| Open-market sale | Common stock | 3,571 | $57.24 | $204K | ||
| Open-market sale | Common stock | 4,929 | $58.57 | $289K | ||
| Open-market sale | Common stock | 1,500 | $59.21 | $89K | ||
| Option exercise | Stock option (right to buy) | 10,000 | $0.00 | - | ||
| Option exercise | Stock option (right to buy) | 10,000 | $0.00 | - |
A Form 144 is notice of an INTENDED sale, not a completed one. It often precedes the Form 4 that reports the trade actually happening.
| Filed | Filer | Relationship | Shares | Market value | Notice |
|---|---|---|---|---|---|
| SARAH GHEUENS | Officer | 30,000 | $914K | View on EDGAR | |
| - | - | - | - | View on EDGAR |
AGIOS PHARMACEUTICALS, INC. (AGIO) had 20 insider filings in the last 90 days, with the most recent on 2026-08-06. The full record for AGIO runs to 57 Form 4 filings, the earliest from 2024-11-12. InsiderAlpha tracks every Form 4, Form 144, and 8-K filing in real time.
No insider purchases of AGIO were filed in the last 90 days.
2 insider sales of AGIO were filed in the last 90 days, totaling $1.06M.
This page tracks AGIO Form 4 insider transactions, Form 144 sale notices, and 8-K material event disclosures in one timeline. Annual 10-K and quarterly 10-Q reports live on the company's SEC EDGAR page.
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Every Form 4 below links to the original document on SEC EDGAR, so the numbers on this page can be checked against the filing they came from.
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