Agios Pharmaceuticals Inc is a biopharmaceutical company focused on the field of cellular metabolism to create differentiated medicines for rare diseases, with a focus on classical hematology. The company's primary focus is to develop potentially transformative small-molecule medicines. Its product candidate, Pyrukynd (mitapivat), is an activator of both wild-type and mutant pyruvate kinase enzymes, developed for the treatment of hemolytic anemias. The other drug candidates in its pipeline include Tebapivat (PK activator), being developed as a potential treatment for MDS-associated anemia and sickle cell disease, AG-181 (PAH stabilizer), AG-236 and others.
| Form 4 transaction type | Transactions | Shares | Total value |
|---|---|---|---|
| Open-market sale | 2 | 34,007 | $1.06M |
| Grant or award | 25 | 216,340 | |
| Option exercise | 29 | 125,157 |
Dollar totals are shown for open-market purchases and sales only. Grants, option exercises, gifts and tax withholding are reported by share count because they are not trades at a market price.
57 Form 4 filings on record, the earliest from Nov 12, 2024, newest first. Filing history page 1 of 2.
| Date | Insider | Transaction | Security | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Open-market sale | Common stock | 30,000 | $30.48 | $914K | ||
| Grant or award | Common stock | 1,447 | $0.00 | - | ||
| Option exercise | Restricted stock units | 1,447 | $0.00 | - | ||
| Option exercise | Restricted stock units | 8,375 | $0.00 | - | ||
| Option exercise | Common stock | 8,375 | $0.00 | - | ||
| Open-market sale | Common stock | 4,007 | $37.56 | $151K | ||
| Grant or award | Stock options (right to buy) | 14,950 | $0.00 | - | ||
| Option exercise | Common stock | 2,816 | $0.00 | - | ||
| Option exercise | Restricted stock units | 2,816 | $0.00 | - | ||
| Grant or award | Restricted stock units | 2,927 | $0.00 | - | ||
| Grant or award | Stock options (right to buy) | 14,950 | $0.00 | - | ||
| Option exercise | Common stock | 2,816 | $0.00 | - | ||
| Option exercise | Restricted stock units | 2,816 | $0.00 | - | ||
| Grant or award | Restricted stock units | 2,927 | $0.00 | - | ||
| Grant or award | Stock options (right to buy) | 14,950 | $0.00 | - | ||
| Option exercise | Common stock | 2,816 | $0.00 | - | ||
| Option exercise | Restricted stock units | 2,816 | $0.00 | - | ||
| Grant or award | Restricted stock units | 2,927 | $0.00 | - | ||
| Jacqualyn A. Fouse - Director | Grant or award | Stock options (right to buy) | 14,950 | $0.00 | - | |
| Jacqualyn A. Fouse - Director | Option exercise | Common stock | 2,816 | $0.00 | - | |
| Jacqualyn A. Fouse - Director | Option exercise | Restricted stock units | 2,816 | $0.00 | - | |
| Jacqualyn A. Fouse - Director | Grant or award | Restricted stock units | 2,927 | $0.00 | - | |
| Option exercise | Common stock | 2,816 | $0.00 | - | ||
| Option exercise | Restricted stock units | 2,816 | $0.00 | - | ||
| Grant or award | Restricted stock units | 2,927 | $0.00 | - | ||
| Grant or award | Stock options (right to buy) | 14,950 | $0.00 | - | ||
| Adams Catherine Owen - Director | Grant or award | Stock options (right to buy) | 14,950 | $0.00 | - | |
| Adams Catherine Owen - Director | Option exercise | Common stock | 2,816 | $0.00 | - | |
| Adams Catherine Owen - Director | Option exercise | Restricted stock units | 2,816 | $0.00 | - | |
| Adams Catherine Owen - Director | Grant or award | Restricted stock units | 2,927 | $0.00 | - | |
| David Scadden - Director | Grant or award | Restricted stock units | 2,927 | $0.00 | - | |
| David Scadden - Director | Grant or award | Stock options (right to buy) | 14,950 | $0.00 | - | |
| David Scadden - Director | Option exercise | Common stock | 2,816 | $0.00 | - | |
| David Scadden - Director | Option exercise | Restricted stock units | 2,816 | $0.00 | - | |
| Cynthia Smith - Director | Option exercise | Restricted stock units | 2,816 | $0.00 | - | |
| Cynthia Smith - Director | Grant or award | Restricted stock units | 2,927 | $0.00 | - | |
| Cynthia Smith - Director | Grant or award | Stock options (right to buy) | 14,950 | $0.00 | - | |
| Cynthia Smith - Director | Option exercise | Common stock | 2,816 | $0.00 | - | |
| Krishnan Viswanadhan - Officer | Option exercise | Performance share units | 3,000 | $0.00 | - | |
| Krishnan Viswanadhan - Officer | Grant or award | Restricted stock units | 3,000 | $0.00 | - | |
| Option exercise | Performance share units | 39,000 | $0.00 | - | ||
| Grant or award | Restricted stock units | 39,000 | $0.00 | - | ||
| James William Burns - Officer | Option exercise | Performance share units | 3,000 | $0.00 | - | |
| James William Burns - Officer | Grant or award | Restricted stock units | 3,000 | $0.00 | - | |
| Option exercise | Performance share units | 3,000 | $0.00 | - | ||
| Grant or award | Restricted stock units | 3,000 | $0.00 | - | ||
| Grant or award | Restricted stock units | 3,000 | $0.00 | - | ||
| Option exercise | Performance share units | 3,000 | $0.00 | - | ||
| Grant or award | Restricted stock units | 3,000 | $0.00 | - | ||
| Option exercise | Performance share units | 3,000 | $0.00 | - | ||
| Grant or award | Restricted stock units | 2,927 | $0.00 | - | ||
| Grant or award | Stock options (right to buy) | 14,950 | $0.00 | - | ||
| Adams Catherine Owen - Director | Option exercise | Common stock | 1,976 | $0.00 | - | |
| Adams Catherine Owen - Director | Option exercise | Restricted stock units | 1,976 | $0.00 | - | |
| Option exercise | Common stock | 1,976 | $0.00 | - | ||
| Option exercise | Restricted stock units | 1,976 | $0.00 | - | ||
| James William Burns - Officer | Option exercise | Common stock | 8,500 | $0.00 | - | |
| James William Burns - Officer | Open-market sale | Common stock | 3,280 | $34.71 | $114K | |
| James William Burns - Officer | Option exercise | Performance share units | 8,500 | $0.00 | - | |
| Option exercise | Common stock | 8,500 | $0.00 | - | ||
| Open-market sale | Common stock | 2,940 | $34.71 | $102K | ||
| Option exercise | Performance share units | 8,500 | $0.00 | - | ||
| Option exercise | Common stock | 8,500 | $0.00 | - | ||
| Open-market sale | Common stock | 3,141 | $34.71 | $109K | ||
| Option exercise | Performance share units | 8,500 | $0.00 | - | ||
| Option exercise | Common stock | 8,500 | $0.00 | - | ||
| Open-market sale | Common stock | 3,262 | $34.71 | $113K | ||
| Option exercise | Performance share units | 8,500 | $0.00 | - | ||
| Krishnan Viswanadhan - Officer | Option exercise | Common stock | 8,100 | $0.00 | - | |
| Krishnan Viswanadhan - Officer | Open-market sale | Common stock | 2,959 | $34.71 | $103K | |
| Krishnan Viswanadhan - Officer | Option exercise | Performance share units | 8,100 | $0.00 | - | |
| Option exercise | Common stock | 25,528 | $0.00 | - | ||
| Option exercise | Common stock | 13,500 | $0.00 | - | ||
| Open-market sale | Common stock | 12,472 | $34.71 | $433K | ||
| Open-market sale | Common stock | 6,596 | $34.71 | $229K | ||
| Option exercise | Performance share units | 25,528 | $0.00 | - | ||
| Option exercise | Performance share units | 13,500 | $0.00 | - | ||
| Krishnan Viswanadhan - Officer | Option exercise | Common stock | 8,100 | $0.00 | - | |
| Krishnan Viswanadhan - Officer | Open-market sale | Common stock | 2,959 | $27.80 | $82K | |
| Krishnan Viswanadhan - Officer | Option exercise | Restricted stock units | 8,100 | $0.00 | - | |
| Theodore James Washburn Jr. - Officer | Open-market sale | Common stock | 5,272 | $28.88 | $152K | |
| Option exercise | Common stock | 8,500 | $0.00 | - | ||
| Option exercise | Common stock | 18,000 | $0.00 | - | ||
| Option exercise | Common stock | 13,000 | $0.00 | - | ||
| Open-market sale | Common stock | 3,870 | $28.96 | $112K | ||
| Open-market sale | Common stock | 8,267 | $28.96 | $239K | ||
| Open-market sale | Common stock | 5,918 | $28.96 | $171K | ||
| Grant or award | Restricted stock units | 48,000 | $0.00 | - | ||
| Grant or award | Stock options (right to buy) | 174,000 | $0.00 | - | ||
| Option exercise | Restricted stock units | 8,500 | $0.00 | - | ||
| Option exercise | Restricted stock units | 18,000 | $0.00 | - | ||
| Option exercise | Restricted stock units | 13,000 | $0.00 | - | ||
| James William Burns - Officer | Option exercise | Common stock | 4,000 | $0.00 | - | |
| James William Burns - Officer | Option exercise | Common stock | 5,666 | $0.00 | - | |
| James William Burns - Officer | Option exercise | Common stock | 4,000 | $0.00 | - | |
| James William Burns - Officer | Option exercise | Common stock | 3,920 | $0.00 | - | |
| James William Burns - Officer | Open-market sale | Common stock | 1,187 | $28.96 | $34K | |
| James William Burns - Officer | Open-market sale | Common stock | 1,187 | $28.96 | $34K | |
| James William Burns - Officer | Open-market sale | Common stock | 1,681 | $28.96 | $49K | |
| James William Burns - Officer | Open-market sale | Common stock | 1,163 | $28.96 | $34K | |
| James William Burns - Officer | Grant or award | Restricted stock units | 14,000 | $0.00 | - | |
| James William Burns - Officer | Grant or award | Stock options (right to buy) | 52,000 | $0.00 | - | |
| James William Burns - Officer | Option exercise | Restricted stock units | 4,000 | $0.00 | - | |
| James William Burns - Officer | Option exercise | Restricted stock units | 4,000 | $0.00 | - | |
| James William Burns - Officer | Option exercise | Restricted stock units | 5,666 | $0.00 | - | |
| James William Burns - Officer | Option exercise | Restricted stock units | 3,920 | $0.00 | - |
A Form 144 is notice of an INTENDED sale, not a completed one. It often precedes the Form 4 that reports the trade actually happening.
| Filed | Filer | Relationship | Shares | Market value | Notice |
|---|---|---|---|---|---|
| SARAH GHEUENS | Officer | 30,000 | $914K | View on EDGAR | |
| - | - | - | - | View on EDGAR |
AGIOS PHARMACEUTICALS, INC. (AGIO) had 20 insider filings in the last 90 days, with the most recent on 2026-08-06. The full record for AGIO runs to 57 Form 4 filings, the earliest from 2024-11-12. InsiderAlpha tracks every Form 4, Form 144, and 8-K filing in real time.
No insider purchases of AGIO were filed in the last 90 days.
2 insider sales of AGIO were filed in the last 90 days, totaling $1.06M.
This page tracks AGIO Form 4 insider transactions, Form 144 sale notices, and 8-K material event disclosures in one timeline. Annual 10-K and quarterly 10-Q reports live on the company's SEC EDGAR page.
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Every Form 4 below links to the original document on SEC EDGAR, so the numbers on this page can be checked against the filing they came from.
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